Budesonide
別名: Entocort EC, Pulmicort, Rhinocort, Benacort, Budelin, Budenofalk, Cortiment, Entocort
> **Important**: Do not crush or allow your pet to chew the enteric-coated capsules. The special coating must remain intact to deliver the medication directly to the intestines. * **Administration**: Can be given with or without food. If your pet has a sensitive stomach, giving it with food may help. * **Side Effects**: While much less common than with standard systemic steroids (like prednisone), watch for increased thirst, increased urination, increased appetite, or excessive panting. * **Stress and Surgery**: Because this drug can suppress the body's natural stress response, inform your veterinarian that your pet is taking budesonide before any surgery, dental procedure, or major stressful event. They may need a temporary dose of a different steroid to help them cope with the stress. * **Compounding**: Because human capsules are often too large for small pets, your veterinarian may have this medication specially compounded at a pharmacy to ensure accurate dosing.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Inflammatory Bowel Disease (IBD) (Clinical Pearl)
- Inflammatory Bowel Disease (IBD) (Clinical Pearl)
- Feline Asthma (Clinical Pearl)
給藥方式
可能的副作用
- Steroid hepatopathy
- HPA-axis suppression
- Hyperadrenocorticism (rare, but risk increases with hepatic dysfunction)
注意事項與禁忌
- Hypersensitivity to budesonide
- Patients with active GI ulcers
- Active systemic infections
- Diabetes mellitus
- Cataracts
- Use with caution in patients with moderate to severe hepatic dysfunction, as they are more likely to develop signs of hypercorticism. Because budesonide suppresses the HPA-axis, animals undergoing stressful procedures (such as surgery) should be considered for exogenous systemic steroid administration. FDA Category C for pregnancy; demonstrated to be embryocidal and teratogenic in rats and rabbits.
藥物相互作用
- CYP3A Inhibitors (e.g., ketoconazole, itraconazole, erythromycin): May decrease the hepatic metabolism of budesonide, leading to increased systemic blood levels and a higher risk of glucocorticoid adverse effects.
- Antacids, H2-blockers, Proton Pump Inhibitors: May increase gastric pH, potentially causing premature dissolution of the enteric coating and reducing the drug's targeted efficacy in the intestines.
- Ketoconazole: Inhibits CYP3A4, significantly increasing systemic budesonide levels and risk of toxicity
- Itraconazole: Inhibits CYP3A4, increasing systemic budesonide levels
- Erythromycin: Inhibits CYP3A4, potentially increasing budesonide levels
- NSAIDs (e.g., Meloxicam, Carprofen): Increased risk of gastrointestinal ulceration and bleeding
常見問題
Budesonide用於寵物有甚麼用途？
> **Important**: Do not crush or allow your pet to chew the enteric-coated capsules. The special coating must remain intact to deliver the medication directly to the intestines. * **Administration**: Can be given with or without food. If your pet has a sensitive stomach, giving it with food may help. * **Side Effects**: While much less common than with standard systemic steroids (like prednisone), watch for increased thirst, increased urination, increased appetite, or excessive panting. * **Stress and Surgery**: Because this drug can suppress the body's natural stress response, inform your veterinarian that your pet is taking budesonide before any surgery, dental procedure, or major stressful event. They may need a temporary dose of a different steroid to help them cope with the stress. * **Compounding**: Because human capsules are often too large for small pets, your veterinarian may have this medication specially compounded at a pharmacy to ensure accurate dosing.
Budesonide對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。