Amiodarone
別名: Cordarone, Pacerone, Nexterone
Your pet has been prescribed amiodarone to treat a serious, potentially life-threatening heart rhythm abnormality. Because this is a very potent medication, careful monitoring is required. * **Informed Consent:** Because experience with this drug in pets is limited and it carries a risk of toxicity, your veterinarian will discuss the risks and benefits with you before starting treatment. * **Administration:** Give exactly as prescribed. Do not skip doses or stop the medication abruptly without consulting your veterinarian. * **Side Effects to Watch For:** Contact your veterinarian immediately if your pet stops eating, vomits, seems unusually lethargic, develops a cough, or has difficulty breathing. * **Follow-up Testing:** Your pet will need regular blood tests to monitor liver and thyroid function, as well as periodic ECGs to ensure the drug is working safely.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- For atrial fibrillation or ventricular arrhythmias primarily in ambulatory patients
- For ventricular arrhythmias secondary to occult cardiomyopathy in Doberman pinschers
- For ventricular tachycardia when other first line drugs (Class I antiarrhythmics ± beta-blockers) are ineffective
- For SVTs or Vtach
- Ventricular and supraventricular arrhythmias, atrial fibrillation, ventricular pre-excitation syndromes
- For conversion of atrial fibrillation or ventricular tachycardia
給藥方式
可能的副作用
- Vomiting
- Anorexia
- Hepatopathy (elevated liver enzymes, bilirubinemia)
- Bradycardia
- Neutropenia
- Thrombocytopenia
- Positive Coombs' test
- Corneal deposits
- Injection site pain (IV)
- Facial pruritus and hyperemia (IV)
- Hind limb weakness (horses)
- Diarrhea (horses)
注意事項與禁忌
- Hypersensitivity to amiodarone or iodine
- Severe sinus-node dysfunction
- Severe sinus bradycardia
- 2nd or 3rd degree AV block
- Bradycardial syncope
- > **High Toxicity Potential:** Clinical experience in veterinary patients is limited. Use only when other less toxic and more commonly used drugs are ineffective. * **Hepatic Effects:** Hepatopathy can occur before clinical signs are noted; routine serial evaluation of liver enzymes and bilirubin is strongly recommended. * **Thyroid Function:** May alter thyroid hormone levels (increases T4 and reverse T3, decreases T3) due to high iodine content. * **Pregnancy:** FDA Category D. Embryotoxic in laboratory animals; congenital thyroid abnormalities detected in offspring. Use only if benefits outweigh risks.
藥物相互作用
- Warfarin (Anticoagulants): Significantly increases serum levels and/or pharmacologic/toxic effects of the anticoagulant.
- Digoxin: Significantly increases serum levels and/or toxic effects of digoxin.
- Cyclosporine: Increases cyclosporine levels; may increase creatinine.
- Lidocaine: Significantly increases serum levels and/or toxic effects of lidocaine.
- Methotrexate: Significantly increases serum levels and/or toxic effects with prolonged amiodarone administration.
- Phenytoin: Significantly increases serum levels and/or toxic effects of phenytoin.
- Procainamide: Significantly increases serum levels and/or toxic effects of procainamide.
- Quinidine: Significantly increases serum levels and/or toxic effects of quinidine.
- Azole Antifungals (ketoconazole, itraconazole): Additive effects on QTc interval; possible serious arrhythmias.
- Cisapride: Additive effects on QTc interval; possible serious arrhythmias.
- Disopyramide: Additive effects on QTc interval; possible serious arrhythmias.
常見問題
Amiodarone用於寵物有甚麼用途？
Your pet has been prescribed amiodarone to treat a serious, potentially life-threatening heart rhythm abnormality. Because this is a very potent medication, careful monitoring is required. * **Informed Consent:** Because experience with this drug in pets is limited and it carries a risk of toxicity, your veterinarian will discuss the risks and benefits with you before starting treatment. * **Administration:** Give exactly as prescribed. Do not skip doses or stop the medication abruptly without consulting your veterinarian. * **Side Effects to Watch For:** Contact your veterinarian immediately if your pet stops eating, vomits, seems unusually lethargic, develops a cough, or has difficulty breathing. * **Follow-up Testing:** Your pet will need regular blood tests to monitor liver and thyroid function, as well as periodic ECGs to ensure the drug is working safely.
Amiodarone對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。