Amikacin Sulfate
別名: Amikin, Amiglyde-V
Amikacin is a powerful antibiotic used for serious infections. Because it is given by injection, your veterinarian will show you how to administer it if you are treating your pet at home. > **Important:** This drug can cause damage to the kidneys and the inner ear (affecting hearing and balance). - **Hydration is crucial:** Ensure your pet always has access to plenty of fresh water to help protect their kidneys. - **Monitor closely:** Contact your vet immediately if you notice changes in thirst or urination (drinking/peeing more or less than usual), loss of balance, head tilt, or apparent hearing loss. - Do not mix this medication with other drugs in the same syringe unless explicitly instructed by your veterinarian.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Empiric therapy
- Susceptible infections
- Sepsis
- Susceptible infections
- Susceptible infections
- Susceptible infections
- Susceptible infections
- Susceptible infections
- Susceptible infections (Neonatal foals)
- Susceptible infections (Neonatal foals)
- Susceptible infections (Adults)
- Susceptible infections (Foals <30 days old)
- Septic joints
- Uterine infusion
給藥方式
可能的副作用
- Nephrotoxicity (tubular necrosis)
- Ototoxicity (auditory and vestibular)
- Neuromuscular blockade
- Facial edema
- Injection site pain/inflammation
- Peripheral neuropathy
- Hypersensitivity reactions
注意事項與禁忌
- Hypersensitivity to aminoglycosides
- Generally contraindicated in rabbits/hares (adversely affects GI flora balance)
- Use with extreme caution in patients with preexisting **renal disease**; requires concomitant monitoring and dosage interval adjustments. Other risk factors for toxicity include age (neonatal and geriatric), fever, sepsis, and dehydration. - **Ototoxicity:** Can cause irreversible ototoxicity; use with caution in 'working' dogs (e.g., seeing-eye, herding, hearing-impaired assistance dogs). - **Neuromuscular Disorders:** Use with caution in patients with conditions like myasthenia gravis due to neuromuscular blocking activity. - **Breed Considerations:** Sighthound dogs (e.g., Greyhounds) have significantly smaller volumes of distribution and may require reduced dosages. - **Food Animals:** Use in food-producing animals is controversial as drug residues may persist for long periods, particularly in renal tissue.
藥物相互作用
- Beta-lactam antibiotics (penicillins, cephalosporins): May have synergistic effects against some bacteria; potential for physical inactivation of aminoglycosides in vitro (do not mix together) and in vivo (patients in renal failure).
- Cephalosporins: Potentially could cause additive nephrotoxicity (controversial, well documented only with older agents like cephaloridine and cephalothin).
- Loop or Osmotic Diuretics (e.g., furosemide, torsemide, mannitol): Concurrent use may increase the nephrotoxic or ototoxic potential of the aminoglycosides.
- NSAIDs: May cause nephrotoxic effects; concurrent use with aminoglycosides should generally be avoided.
- Other Nephrotoxic Drugs (e.g., cisplatin, amphotericin B, polymyxin B, vancomycin): Potential for increased risk for nephrotoxicity.
- Neuromuscular blocking agents & General anesthetics: Concomitant use could potentiate neuromuscular blockade.
常見問題
Amikacin Sulfate用於寵物有甚麼用途？
Amikacin is a powerful antibiotic used for serious infections. Because it is given by injection, your veterinarian will show you how to administer it if you are treating your pet at home. > **Important:** This drug can cause damage to the kidneys and the inner ear (affecting hearing and balance). - **Hydration is crucial:** Ensure your pet always has access to plenty of fresh water to help protect their kidneys. - **Monitor closely:** Contact your vet immediately if you notice changes in thirst or urination (drinking/peeing more or less than usual), loss of balance, head tilt, or apparent hearing loss. - Do not mix this medication with other drugs in the same syringe unless explicitly instructed by your veterinarian.
Amikacin Sulfate對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。