Acetohydroxamic Acid
別名: Lithostat, Uronefrex
**Acetohydroxamic acid** is used to help dissolve stubborn bladder stones and treat specific urinary tract infections in dogs. * **Give exactly as prescribed** and do not give to pregnant animals or cats. * > **Important**: This medication has a high risk of side effects. * **Watch for and report immediately**: Persistent or severe vomiting, loss of appetite, changes in urine color (dark or bloody), yellowing of the whites of the eyes (jaundice), or extreme tiredness/decreased energy.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Adjunctive therapy of persistent struvite uroliths and persistent urease-producing bacteria after treating with antibiotics and calculolytic diets
給藥方式
可能的副作用
- Anorexia
- Vomiting
- Mouth and esophageal ulcers
- Hemolytic anemia
- Hyperbilirubinemia
- Bilirubinuria
- CNS disturbances (anxiety, depression, tremulousness)
- Reticulocytosis
- Bone marrow depression
- Phlebitis
- Skin rashes and alopecia
注意事項與禁忌
- Cats (highly toxic)
- Patients with poor renal function (e.g., serum creatinine >2.5 mg/dL)
- Pregnancy (FDA Category X - severe teratogenic effects)
- > **WARNING**: Do NOT use in cats; AHA is highly toxic to felines. * **Renal Impairment**: Contraindicated in patients with poor renal function (serum creatinine > 2.5 mg/dL). * **Pregnancy**: Contraindicated during pregnancy (FDA Category X). In pregnant beagles, doses of 25 mg/kg/day caused cardiac, coccygeal, and abdominal wall abnormalities in puppies. Higher doses caused leg deformities and significant encephalopathologies. * **Adverse Effects**: High incidence of adverse effects limits its clinical usefulness. Close monitoring is required.
藥物相互作用
- Iron salts: AHA may chelate iron salts in the gut if given concomitantly, reducing absorption.
- Methenamine: AHA may have a synergistic effect with methenamine in inhibiting urine pH increases caused by urease-producing Proteus spp., and may potentiate antibacterial effects.
- Alcohol: In humans, concurrent use of AHA with alcohol has resulted in skin rashes.
常見問題
Acetohydroxamic Acid用於寵物有甚麼用途？
**Acetohydroxamic acid** is used to help dissolve stubborn bladder stones and treat specific urinary tract infections in dogs. * **Give exactly as prescribed** and do not give to pregnant animals or cats. * > **Important**: This medication has a high risk of side effects. * **Watch for and report immediately**: Persistent or severe vomiting, loss of appetite, changes in urine color (dark or bloody), yellowing of the whites of the eyes (jaundice), or extreme tiredness/decreased energy.
Acetohydroxamic Acid對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。