乙醯氧肟酸
別名: Lithostat, Uronefrex
藥物類別: Urease Inhibitor
此藥物用於協助溶解犬隻頑固的膀胱結石及治療特定的泌尿道感染。 * 請**嚴格按照醫囑給藥**，絕對不可用於懷孕動物或貓咪。 * > **重要提示**：此藥物產生副作用的風險較高。 * **若發現以下症狀請立即聯繫獸醫師**：持續或嚴重的嘔吐、食慾不振、尿液顏色改變（變深或帶血）、眼白變黃（黃疸）或極度疲倦/活力下降。
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Adjunctive therapy of persistent struvite uroliths and persistent urease-producing bacteria after treating with antibiotics and calculolytic diets
給藥方式
PO
可能的副作用
- Anorexia
- Vomiting
- Mouth and esophageal ulcers
- Hemolytic anemia
- Hyperbilirubinemia
- Bilirubinuria
- CNS disturbances (anxiety, depression, tremulousness)
- Reticulocytosis
- Bone marrow depression
- Phlebitis
- Skin rashes and alopecia
注意事項與禁忌
- Cats (highly toxic)
- Patients with poor renal function (e.g., serum creatinine >2.5 mg/dL)
- Pregnancy (FDA Category X - severe teratogenic effects)
- > **WARNING**: Do NOT use in cats; AHA is highly toxic to felines. * **Renal Impairment**: Contraindicated in patients with poor renal function (serum creatinine > 2.5 mg/dL). * **Pregnancy**: Contraindicated during pregnancy (FDA Category X). In pregnant beagles, doses of 25 mg/kg/day caused cardiac, coccygeal, and abdominal wall abnormalities in puppies. Higher doses caused leg deformities and significant encephalopathologies. * **Adverse Effects**: High incidence of adverse effects limits its clinical usefulness. Close monitoring is required.
藥物相互作用
- Iron salts: AHA may chelate iron salts in the gut if given concomitantly, reducing absorption.
- Methenamine: AHA may have a synergistic effect with methenamine in inhibiting urine pH increases caused by urease-producing Proteus spp., and may potentiate antibacterial effects.
- Alcohol: In humans, concurrent use of AHA with alcohol has resulted in skin rashes.
常見問題
乙醯氧肟酸用於寵物有甚麼用途？
此藥物用於協助溶解犬隻頑固的膀胱結石及治療特定的泌尿道感染。 • 請嚴格按照醫囑給藥，絕對不可用於懷孕動物或貓咪。 • > 重要提示：此藥物產生副作用的風險較高。 • 若發現以下症狀請立即聯繫獸醫師：持續或嚴重的嘔吐、食慾不振、尿液顏色改變（變深或帶血）、眼白變黃（黃疸）或極度疲倦/活力下降。
乙醯氧肟酸對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。