피릴라민 말레산염

용도

• Antihistamine
• Antihistamine
• Adjunctive treatment of aseptic laminitis
• Antihistamine
• Antihistamine (Foals)
• Antihistamine
• Antihistamine
• Antihistamine
• Antihistamine
• Antihistamine

투여 방법

가능한 부작용

• CNS stimulation (nervousness, insomnia, convulsions, tremors, ataxia)
• Palpitation
• GI disturbances
• CNS depression (sedation)
• Muscular weakness
• Anorexia
• Lassitude
• Incoordination

주의사항 및 금기

• Should not supersede the use of other emergency drugs and procedures (e.g., epinephrine for acute anaphylaxis)
• > **Emergency Use Warning**: Antihistamines are not a substitute for epinephrine and supportive care in cases of severe, acute anaphylaxis. * **Skin Testing**: Antihistamines suppress the wheal and flare response. Discontinue at least 4 days prior to intradermal allergy testing. * **Pregnancy**: Probably safe at usual doses, though high-dose rodent studies showed increased fetal death. No teratogenic effects noted in human studies. * **Nursing**: Unknown if it enters milk. * **Regulatory**: Products containing pseudoephedrine are subject to strict regulations (List 1 chemical) due to illicit methamphetamine manufacturing. Pyrilamine is an ARCI Class 3 drug in racing horses.

약물 상호작용

• Anticoagulants (heparin, warfarin): Antihistamines may partially counteract the anticoagulation effects of heparin or warfarin.
• CNS Depressant Drugs: Increased sedation can occur if pyrilamine is combined with other CNS depressant drugs.
• Epinephrine: Pyrilamine may enhance the effects of epinephrine.

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