아세트아미노펜 (파라세타몰)

용도

• Mild to moderate pain / Antipyretic
• Mild to moderate pain (Pardale-V preparation)
• All indications

투여 방법

가능한 부작용

• Hepatotoxicity (dose-dependent)
• Methaemoglobinaemia (especially in cats)
• Facial edema
• Cyanosis

주의사항 및 금기

• Cats (absolute contraindication due to fatal toxicosis)
• Patients with pre-existing severe hepatic impairment
• > **Feline Toxicity:** Do not use in cats. They lack the glucuronyl transferase enzymes required to metabolize the drug, leading to fatal methaemoglobinaemia and hepatotoxicity even at very low doses. - Use with caution in dogs with pre-existing liver disease. - The combination of an NSAID and paracetamol for perioperative analgesia is common in human medicine but has not undergone rigorous safety or efficacy investigation in dogs.

약물 상호작용

• Metoclopramide: Enhances the absorption of paracetamol, thereby enhancing its clinical and potentially toxic effects.
• Cytochrome P450 Inducers (e.g., Phenobarbital, certain NSAIDs): May increase the production of toxic metabolites (NAPQI), enhancing the risk of hepatotoxicity.

자주 묻는 질문