아산화질소 (웃음가스)

용도

• Adjunct for induction and maintenance of anaesthesia
• Adjunct for induction and maintenance of anaesthesia

투여 방법

가능한 부작용

• Diffusion hypoxia (if oxygen is not supplemented upon discontinuation)
• Megaloblastic changes in bone marrow (with exposure lasting a few hours)
• Agranulocytosis (with prolonged exposure of a few days)

주의사항 및 금기

• Patients with air-filled spaces within the body (e.g., pneumothorax, gastric dilatation/GDV, intestinal obstruction)
• Marked respiratory compromise (due to hypoxia risks)
• Raised intracranial pressure (due to associated increases in cerebral blood flow)
• **Human Safety & Scavenging:** Prolonged exposure can have serious adverse effects on human health. Active scavenging is essential. > **Important:** N2O is **not** absorbed by activated charcoal in passive scavenging systems. **Hypoxia Risk:** A minimum oxygen concentration of 30% is required during anaesthesia. The inspired concentration of oxygen may fall to critically low levels when N2O is used in rebreathing circuits during low flow rates. Do not use in such systems unless the inspired oxygen concentration can be measured on a breath-by-breath basis. **Diffusion Hypoxia:** Always supplement with 100% oxygen for 5-10 minutes after turning off N2O.

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