미르타자핀

용도

• As an appetite stimulant and/or antiemetic
• As an appetite stimulant and/or antiemetic
• As an appetite stimulant and/or antiemetic
• Appetite stimulation
• As an appetite stimulant and/or antiemetic
• As an appetite stimulant and/or antiemetic
• Appetite stimulation / Management of social fears

투여 방법

가능한 부작용

• Drowsiness/sedation
• Vocalization (especially in cats)
• Increased affection (cats)
• Hypotension
• Tachycardia
• Sedation (common and can be profound)
• Increased vocalization (especially in cats)
• Altered behavior and increased interaction with others
• Blood dyscrasias (reported in humans)

주의사항 및 금기

• Hypersensitivity to mirtazapine
• Use of monoamine oxidase inhibitors (MAOIs, e.g., selegiline) within the past 14 days
• Pre-existing haematological disease
• Use with caution in patients with known **cardiac disease** or **cerebrovascular disease** that could be exacerbated by hypotension. * Monitor patients with **renal impairment, renal failure, or hepatic disease** closely, as clearance may be reduced. * Use with caution in patients with **diabetes mellitus**, as antidepressants may indirectly affect blood glucose concentrations. * Due to weak anticholinergic activity, use vigilance in patients susceptible to these effects (e.g., **urinary retention, prostatic hypertrophy, acute closed-angle glaucoma, increased intraocular pressure, GI obstruction, or ileus**). * May impair concentration and alertness in active animals. * Use cautiously in patients with pre-existing **hematological disease** (leukopenia, neutropenia, thrombocytopenia), as it has been rarely associated with blood dyscrasias in humans.

약물 상호작용

• CLONIDINE: Mirtazapine may cause increases in blood pressure
• DIAZEPAM (and other benzodiazepines): Minimal effects on mirtazapine blood levels, but may cause additive impairment of motor skills
• FLUVOXAMINE: May cause increased serum concentrations of mirtazapine
• LINEZOLID: Increased risk for serotonin syndrome
• SELEGILINE, AMITRAZ: Increased risk for serotonin syndrome; MAO inhibitors considered contraindicated with mirtazapine
• TRAMADOL: Increased risk for serotonin syndrome
• Other behaviour-modifying drugs (e.g., SSRIs, MAOIs): Increased risk of serotonin syndrome

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