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투여 방법

가능한 부작용

• Mild lethargy or sedation (rare compared to first-generation antihistamines)
• Vomiting
• Diarrhea
• Dry mouth (xerostomia)
• Decreased tear production

주의사항 및 금기

• Known hypersensitivity to loratadine or desloratadine
• Use with caution in patients with severe hepatic impairment
• Use with caution in patients with keratoconjunctivitis sicca (dry eye)
• Use with caution in animals with **hepatic impairment**, as loratadine is extensively metabolized in the liver. Dose adjustments may be necessary. > **Allergy Testing:** Antihistamines should be withdrawn at least 1 to 2 weeks prior to intradermal allergy testing to prevent false-negative results.

약물 상호작용

• Ketoconazole: May inhibit the metabolism of loratadine, increasing plasma concentrations
• Erythromycin: May inhibit the metabolism of loratadine, increasing plasma concentrations
• Cimetidine: May inhibit the metabolism of loratadine, increasing plasma concentrations
• Amiodarone: May increase loratadine levels via CYP inhibition

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