류프로라이드

용도

• Adrenal associated endocrinopathy (30-day formulation)
• Adrenal associated endocrinopathy (3-month formulation)
• Adrenal associated endocrinopathy (4-month formulation)
• Adrenal associated endocrinopathy (30-day formulation, weight-based)
• Adrenal associated endocrinopathy (1-month depot form)
• Inappropriate egg laying in Cockatiels (if management changes fail)
• Inhibit egg laying in pet birds
• Macroorchidism

투여 방법

가능한 부작용

• Pain or irritation at the injection site
• Dyspnea (reported in ferrets)
• Lethargy (reported in ferrets)
• Tachyphylaxis (higher dosages required over time to obtain the same effect in ferrets)
• Transient worsening of clinical signs (flare effect) shortly after initial administration

주의사항 및 금기

• Pregnancy (FDA Category X - major fetal abnormalities may result)
• Nursing/lactating animals (use with extreme caution, excretion in milk is unknown)
• > **Pregnancy Warning**: Leuprolide is highly teratogenic. Pregnant women should handle this medication with extreme caution, and it must never be administered to pregnant animals. * **Tachyphylaxis**: Ferrets may develop a tolerance to the drug over time, necessitating dose escalations. * **Laboratory Interference**: Diagnostic tests measuring pituitary gonadotrophic and gonadal functions may be misleading during therapy and for several months after discontinuation. * **Handling**: Depot formulations contain microspheres. Freezing reconstituted depot suspensions is controversial; the manufacturer warns against freezing as it may destroy the microspheres, though some compounding pharmacies do freeze individual aliquots.

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