글리메피리드

용도

• Treatment of NIDDM
• Treatment of NIDDM

투여 방법

가능한 부작용

• Hypoglycemia
• Dizziness
• Asthenia
• Liver function impairment (rare)
• Allergic respiratory reactions (rare)
• Dermatologic reactions (rare)
• Hematologic reactions (rare)

주의사항 및 금기

• Hypersensitivity to glimepiride or other sulfonylureas
• Diabetic ketoacidosis (DKA)
• > **Warning:** Do not confuse glimepiride with other sulfonylureas such as glipizide or glyburide. - **Pregnancy:** FDA Category C. Animal studies show intrauterine deaths secondary to maternal hypoglycemia. Avoid use during pregnancy. - **Nursing:** Excreted in maternal milk; manufacturer recommends discontinuing in nursing mothers. - **Hepatic/Renal Impairment:** Use with caution as metabolism and excretion may be delayed, increasing the risk of hypoglycemia.

약물 상호작용

• Azole Antifungals (ketoconazole, itraconazole, fluconazole): May increase plasma levels of glimepiride
• Beta-Blockers: May potentiate hypoglycemic effect
• Chloramphenicol: May displace glimepiride from plasma proteins
• Corticosteroids: May reduce efficacy
• Thiazide Diuretics: May reduce hypoglycemic efficacy
• Isoniazid: May reduce hypoglycemic efficacy
• Niacin: May reduce hypoglycemic efficacy
• Phenothiazines: May reduce hypoglycemic efficacy
• Phenytoin: May reduce hypoglycemic efficacy
• Sulfonamides: May displace glimepiride from plasma proteins
• Sympathomimetic Agents: May reduce hypoglycemic efficacy
• Warfarin: May displace glimepiride from plasma proteins

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