세파드록실

용도

• UTI
• Skin, pyoderma
• Systemic, orthopedic infections
• Susceptible gram-positive infections
• Susceptible gram-negative infections
• Susceptible infections
• Susceptible infections
• Susceptible infections (skin, soft tissue, GU)
• Susceptible Staph infections
• UTI
• Skin, pyoderma
• Systemic, orthopedic infections
• Susceptible gram-positive infections
• Susceptible gram-negative infections

투여 방법

가능한 부작용

• Anorexia
• Vomiting
• Diarrhea
• Hypersensitivity reactions (rash, fever, eosinophilia, anaphylaxis)
• Antibiotic-associated diarrhea/superinfections
• Tachypnea (rare)
• Neurotoxicity (at high doses)
• Neutropenia/thrombocytopenia (rare, prolonged use)
• Hepatitis (rare)
• Nephrotoxicity (rare)

주의사항 및 금기

• Known hypersensitivity to cephalosporins
• Septicemia, shock, or grave illness (oral absorption is unreliable; parenteral routes required)
• > **Cross-Reactivity Warning:** Use cautiously in patients with documented hypersensitivity to other beta-lactam antibiotics (e.g., penicillins, carbapenems) due to potential cross-reactivity (up to 15% in humans; unknown in veterinary patients). * **Renal Impairment:** Patients with diminished renal function may require dose adjustments and intensified renal monitoring, as the drug is primarily excreted unchanged in the urine. * **Laboratory Interference:** * May cause false-positive urine glucose tests when using cupric sulfate solutions (e.g., Clinitest®). * May falsely elevate serum/urine creatinine values when using the Jaffe reaction. * May cause a false-positive direct Coombs' test. * May falsely elevate 17-ketosteroid values in urine.

약물 상호작용

• Probenecid: Competitively blocks the tubular secretion of most cephalosporins, thereby increasing serum levels and serum half-lives.

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