トリエンチン

使用用途

• As a chelator for copper hepatotoxicity
• As a chelator for copper hepatotoxicity
• As a chelator for copper hepatotoxicity
• Copper hepatotoxicosis

投与方法

考えられる副作用

• Acute renal failure (rare but reported in dogs)
• Iron deficiency anemia (with long-term use)
• Topical contact dermatitis (if powder contacts skin)
• Nausea
• Vomiting
• Abdominal pain
• Melaena (dark, tarry stools)
• Weakness
• Copper deficiency (with chronic therapy)

注意事項と禁忌

• Hypersensitivity to trientine
• Cystinuria
• Rheumatoid arthritis
• Biliary cirrhosis
• No specific contraindications available in the monograph, but should be used with caution in patients without confirmed copper storage disease.
• **Teratogenicity:** Trientine is a potential teratogen (FDA Category C). It should only be used in pregnant animals when the benefits to the mother clearly outweigh the risks to the offspring. Exercise caution in nursing patients. **Handling Warning:** The drug can cause topical dermatitis. It **must be given in an intact capsule** and should never be opened or sprinkled on food. If the powder accidentally contacts human or animal skin, wash the area immediately with water.

薬物相互作用

• Iron: Iron and trientine mutually inhibit the absorption of one another. Separate doses by at least 2 hours.
• Zinc: Trientine may chelate zinc and other essential minerals, reducing their absorption. Separate doses by at least 2 hours.
• Iron supplements: Inhibits absorption of iron; separate doses by a minimum of 2 hours
• Zinc supplements: Inhibits absorption of zinc; separate doses by a minimum of 2 hours
• Other mineral supplements: Inhibits absorption of minerals; separate doses by a minimum of 2 hours

よくある質問