チロトロピン (甲状腺刺激ホルモン)

使用用途

• TSH stimulation test
• TSH stimulation test
• TSH stimulation test
• TSH stimulation test
• TSH stimulation test

投与方法

考えられる副作用

• Hypersensitivity reactions (especially with repeated injections of human-derived proteins in animals)
• Clinical signs of hyperthyroidism (with chronic administration or high doses)
• Anaphylactic responses (specifically associated with chemical grade/bovine TSH; recombinant forms are generally well tolerated)

注意事項と禁忌

• Adrenocortical insufficiency (untreated Addison's disease)
• Hyperthyroidism
• Coronary thrombosis
• Hypersensitivity to bovine thyrotropin or human proteins
• Repeated administration is not advisable
• Patients currently receiving levothyroxine therapy
• Use of chemical grade TSH (due to anaphylaxis risk)
• > **Hypersensitivity Warning:** Because the commercially available product is derived from human sources, hypersensitivity reactions may occur in patients sensitive to human proteins, particularly with repeated use. * **Pregnancy:** FDA Category C. Animal studies have shown an adverse effect on the fetus, but there are no adequate studies in humans. * **Nursing:** Unknown if excreted in milk, but unlikely to be clinically significant when used for a one-time diagnostic test.

薬物相互作用

• Anabolic or androgenic steroids: May decrease serum T4 levels, making the TSH stimulation test hard to interpret
• Carbimazole: May decrease serum T4 levels, making the TSH stimulation test hard to interpret
• Barbiturates: May decrease serum T4 levels, making the TSH stimulation test hard to interpret
• Corticosteroids: May decrease serum T4 levels, making the TSH stimulation test hard to interpret
• Diazepam: May decrease serum T4 levels, making the TSH stimulation test hard to interpret
• Heparin: May decrease serum T4 levels, making the TSH stimulation test hard to interpret
• Mitotane: May decrease serum T4 levels, making the TSH stimulation test hard to interpret
• Phenylbutazone: May decrease serum T4 levels, making the TSH stimulation test hard to interpret
• Phenytoin: May decrease serum T4 levels, making the TSH stimulation test hard to interpret
• Salicylates: May decrease serum T4 levels, making the TSH stimulation test hard to interpret

よくある質問