ラミプリル

使用用途

• Treatment of arterial hypertension
• CHF
• Treatment of heart failure

投与方法

考えられる副作用

• Anorexia
• Vomiting
• Diarrhea
• Weakness
• Hypotension
• Hyperkalemia

注意事項と禁忌

• Hypersensitivity to ACE inhibitors
• Clinical cases of vascular stenosis (e.g., aortic stenosis)
• Obstructive hypertrophic cardiomyopathy
• Concurrent use with potassium-sparing diuretics (per UK label)
• > **Pregnancy Warning:** ACE inhibitors carry a 'black box' warning in humans for fetal injury/death during the 2nd and 3rd trimesters. Do not use in pregnant or lactating animals unless the benefits clearly outweigh the risks. * **Caution** in patients with hyponatremia, coronary or cerebrovascular insufficiency, preexisting hematologic abnormalities, or a collagen vascular disease (e.g., SLE). * May cause a reversible decrease in localization and excretion of certain renal imaging agents in patients with renal artery stenosis.

薬物相互作用

• Aspirin: May potentially negate the decrease in systemic vascular resistance induced by ACE inhibitors (though low-dose aspirin did not affect enalaprilat hemodynamics in one dog study).
• Antidiabetic agents (insulin, oral agents): Possible increased risk for hypoglycemia; enhanced monitoring recommended.
• Diuretics (e.g., furosemide, hydrochlorothiazide): Potential for increased hypotensive effects.
• Diuretics, potassium sparing (e.g., spironolactone, triamterene): Increased hyperkalemic effects; enhanced monitoring of serum potassium required.
• NSAIDs: Potential for increased risk of renal dysfunction or hyperkalemia.
• Potassium supplements: Increased risk for hyperkalemia.

よくある質問