オキサゼパム

使用用途

• Appetite stimulant
• Appetite stimulant (hepatic lipidosis)
• Appetite stimulant
• Fears and phobias
• Fears and phobias
• Feline urine marking
• Spraying or overgrooming
• Fears and phobias
• Fears and phobias
• Fears and phobias
• Fears and phobias
• Fears and phobias

投与方法

考えられる副作用

• Sedation (most common)
• Ataxia
• Paradoxical excitability, vocalization, or aggression
• Rebound anxiety or behavior worsening (if withdrawn abruptly)
• Rare precipitation of tonic-clonic seizures
• Rare idiosyncratic fulminant hepatic failure (cats)

注意事項と禁忌

• Known benzodiazepine hypersensitivity
• Acute narrow angle glaucoma
• **Important Warnings & Precautions:** * **Hepatic Dysfunction:** Use with caution. While less susceptible to accumulation than other benzodiazepines, rare anecdotal reports link oxazepam to fulminant hepatic failure in cats. * **Myasthenia Gravis:** Benzodiazepines may exacerbate muscle weakness. * **Seizure Disorders:** Use with caution in susceptible patients; rarely, it has precipitated tonic-clonic seizures. * **Pregnancy & Nursing:** FDA Category D (teratogenic effects noted in animal models). Excreted in maternal milk; neonates metabolize the drug slowly, leading to potential toxic accumulation. Avoid in nursing mothers. * **Withdrawal:** Avoid abrupt discontinuation to prevent rebound behavioral effects.

薬物相互作用

• CNS Depressant Drugs (barbiturates, narcotics, anesthetics): Additive CNS depression effects may occur.
• Phenytoin: May decrease oxazepam concentrations.
• Probenecid: May impair glucuronide conjugation (in dogs) and prolong effects.
• Rifampin: May induce hepatic microsomal enzymes and decrease the pharmacologic effects of benzodiazepines.
• St. John's Wort: May decrease oxazepam effectiveness.
• Theophyllines: May decrease oxazepam effectiveness.

よくある質問