硫酸マグネシウム (エプソム塩)

使用用途

投与方法

考えられる副作用

• Hypermagnesemia
• Muscle weakness
• Respiratory depression
• Hypotension
• Cardiac arrhythmias or heart block
• Diarrhea (with oral administration)
• Somnolence
• CNS depression
• Coma
• Muscular weakness
• Bradycardia
• Prolonged Q-T intervals
• Neuromuscular blockade
• Cardiac arrest

注意事項と禁忌

• Renal failure or severe renal impairment
• Heart block or significant myocardial damage
• Myasthenia gravis (can exacerbate weakness)
• Heart block
• Myocardial damage
• Renal impairment
• Renal failure
• Use with extreme caution in patients with impaired renal function, as magnesium is primarily excreted by the kidneys. Monitor ECG, respiratory rate, and deep tendon reflexes during intravenous administration. Have intravenous calcium (e.g., calcium gluconate) readily available as an antidote for magnesium toxicity.

薬物相互作用

• Neuromuscular blocking agents: Potentiates neuromuscular blockade
• CNS depressants: Additive CNS depression
• Calcium channel blockers: Risk of profound hypotension and cardiovascular collapse
• Barbiturates: Additive CNS depression effects
• General anaesthetics: Additive CNS depression effects
• Non-depolarizing neuromuscular blocking agents: Risk of severe neuromuscular blockage
• Digitalis glycosides: Serious conduction disturbances can occur

よくある質問