リチウム

使用用途

• Bone marrow suppression / neutropenia
• Contraindicated

投与方法

考えられる副作用

• Nausea
• Diarrhoea
• Muscle weakness
• Fatigue
• Polyuria (PU)
• Polydipsia (PD)
• Seizures
• Hypothyroidism (blocks release of T3 and T4)

注意事項と禁忌

• Cats (highly toxic)
• Renal impairment
• Cardiac disease
• Conditions with sodium imbalance (e.g., hypoadrenocorticism)
• Dehydration
• > **WARNING**: Do not use in cats as lithium is highly toxic to them. > **WARNING**: Avoid in patients with renal impairment, cardiac disease, or sodium imbalance. Only use in patients showing no signs of dehydration. * **Therapeutic Monitoring**: Assess serum lithium concentration every 3 months (target: 0.5-1.8 mmol/l). * **Thyroid Monitoring**: Assess thyroid status every 6 months, as lithium can block the release of T3 and T4.

薬物相互作用

• ACE inhibitors: Reduces lithium excretion, increasing the risk of toxicity
• Loop diuretics: Reduces lithium excretion and causes sodium depletion, worsening toxicity
• Thiazide diuretics: Reduces lithium excretion and causes sodium depletion, worsening toxicity
• NSAIDs: Reduces lithium excretion, increasing the risk of toxicity
• Theophylline: May increase the excretion of lithium, potentially reducing efficacy
• Neostigmine: Lithium antagonizes the effects of neostigmine
• Pyridostigmine: Lithium antagonizes the effects of pyridostigmine
• Diltiazem: Concurrent administration may result in neurotoxicity
• Verapamil: Concurrent administration may result in neurotoxicity

よくある質問