イソプロテレノール

使用用途

• Sinoatrial arrest, sinus bradycardia, complete AV block
• Short-term bronchodilatation
• Sinoatrial arrest, sinus bradycardia, complete AV block
• Sinoatrial arrest, sinus bradycardia, complete AV block
• Sinoatrial arrest, sinus bradycardia, complete AV block
• Sinoatrial arrest, sinus bradycardia, complete AV block
• Sinoatrial arrest, sinus bradycardia, complete AV block
• Adjunctive treatment for bradycardia associated with calcium channel blocker overdose

投与方法

考えられる副作用

• Tachycardia
• Ventricular arrhythmias (highly arrhythmogenic)
• Anxiety and excitability
• Tremors
• Headache
• Weakness
• Vomiting

注意事項と禁忌

• Tachycardias or AV block caused by cardiac glycoside (digoxin) intoxication
• Ventricular arrhythmias that do not require increased inotropic activity
• > **Warning:** Isoproterenol is highly arrhythmogenic (more so than dopamine or dobutamine). Use with extreme caution. * **Disease States:** Use with caution in patients with coronary insufficiency, hyperthyroidism, renal disease, hypertension, or diabetes. * **Shock:** Isoproterenol is **not** a substitute for adequate fluid replacement in shock. * **Pregnancy:** FDA Category C. Animal studies show adverse fetal effects. Use cautiously as a last resort when benefits clearly outweigh risks. * **Lactation:** Rapidly deactivated in the gut, so it is unlikely to pose much risk to nursing offspring.

薬物相互作用

• General Anesthetics (cyclopropane, halogenated hydrocarbons): Increased risk of developing arrhythmias. Propranolol may be administered should these occur.
• Beta-Blockers: May antagonize isoproterenol's cardiac, bronchodilating, and vasodilating effects. Can be used to treat isoproterenol-induced tachycardia, but use with caution in bronchospastic disease.
• Digoxin (Digitalis glycosides): Increased risk of arrhythmias.
• Oxytocic Agents: Hypertension may result if used concurrently.
• Other Sympathomimetic Agents (e.g., phenylpropanolamine): Should not be administered concurrently as increased toxicity may result.
• Theophylline: May increase the risk for theophylline toxicity.

よくある質問