イルベサルタン

使用用途

• As an alternative to ACE inhibitors for treatment of hypertension associated with renal insufficiency

投与方法

考えられる副作用

• Diarrhea
• Dyspepsia (indigestion)
• Fatigue or somnolence
• Orthostatic hypotension
• Dizziness

注意事項と禁忌

• Pregnancy (teratogenic)
• Nursing/lactating animals
• Hypotension
• Uncorrected volume depletion
• Uncorrected sodium depletion
• Hypersensitivity to irbesartan
• **Important Warnings:** * **Hypovolemia/Hyponatremia:** Patients who are volume- or sodium-depleted must have these deficits corrected prior to initiating therapy to avoid acute hypotensive crises. * **Pregnancy Warning:** Irbesartan is highly teratogenic (FDA Category D). It causes fetal abnormalities (renal pelvic cavitation, hydroureter) and increased maternal death/spontaneous abortion. Discontinue immediately if pregnancy is detected. * **Hypotension:** Do not use in patients with pre-existing hypotension.

薬物相互作用

• Other antihypertensive agents (e.g., amlodipine, ACE inhibitors): Increased risk of additive hypotension. Use with caution and monitor blood pressure closely.
• Diuretics: May exacerbate volume depletion and increase the risk of severe hypotension.

よくある質問