イオヘキソール

使用用途

• Estimate GFR (single sample method)
• Contrast agent for suspected GI perforation
• Contrast agent (GI abnormalities, transit time)
• Estimate GFR (2-4 sample method)
• Estimate GFR (single sample method)
• Contrast agent for suspected GI perforation

投与方法

考えられる副作用

• Hypersensitivity reactions (rare)
• Nephrotoxicity (slight risk)
• Pain or heat sensation at injection site (less common than with ionic agents)

注意事項と禁忌

• Prior hypersensitivity reaction to iohexol or iodine-containing products
• > **Hypersensitivity**: Always monitor for signs of anaphylaxis or allergic reactions, even though they are rare in veterinary patients. * **Nephrotoxicity**: While the risk is low, use with caution in patients with pre-existing severe renal impairment or dehydration; ensure adequate hydration prior to intravascular administration. * **Pregnancy**: FDA Category B. Animal studies have not demonstrated fetal risk, but use in late pregnancy carries potential theoretical risk to fetal thyroid function. * **Laboratory Interference**: Prior use of iohexol can reduce the iodine-binding capacity of thyroid tissue for up to 2 weeks, interfering with iodine-dependent thyroid function tests.

薬物相互作用

• Drugs that prolong QTc interval (e.g., amiodarone, cisapride, procainamide, quinidine, sotalol, dolasetron, moxifloxacin): May cause additive prolongation of the QTc interval, though iohexol causes less prolongation than diatrizoate.
• Iodine Isotopes: May alter binding to thyroid tissue for up to two weeks, affecting certain thyroid treatments or scans.
• Phenothiazines: May increase the risk for lowering the seizure threshold, especially when iohexol is used intrathecally.

よくある質問