ヒドロコルチゾン

使用用途

• Focal or multifocal pruritic/inflammatory lesions
• Focal or multifocal pruritic/inflammatory lesions

投与方法

考えられる副作用

• Skin atrophy (with long-term use)
• Skin fragility
• Superficial follicular cysts (milia)
• Comedones
• HPA axis suppression (rare, but possible with long-term use)
• Weight loss (catabolic effect)
• Cutaneous atrophy
• Iatrogenic hyperadrenocorticism (PU/PD, elevated liver enzymes)
• Vomiting
• Diarrhoea
• Gastrointestinal ulceration
• Increased urine glucose levels
• Decreased serum T3 and T4 values
• Hypothalamic-pituitary axis suppression (with prolonged use)

注意事項と禁忌

• Tuberculosis of the skin
• Pregnancy (relative contraindication)
• Pregnant animals
• Renal disease (systemic use generally contraindicated)
• Diabetes mellitus (systemic use generally contraindicated)
• > **Important**: Clients should wash hands after application or wear gloves. Avoid contact with eyes. Do not allow the animal to lick or chew at affected sites for at least 20-30 minutes after application. Residual activity may affect intradermal or allergy serum tests; stop use 2 weeks prior to allergy testing.

薬物相互作用

• NSAIDs: Increased risk of gastrointestinal ulceration
• Insulin: Glucocorticoids antagonize the effect of insulin
• Phenobarbital: May accelerate the metabolism of corticosteroids
• Itraconazole: May decrease the metabolism of corticosteroids
• Acetazolamide: Increased risk of hypokalaemia
• Amphotericin B: Increased risk of hypokalaemia
• Furosemide: Increased risk of hypokalaemia
• Thiazide diuretics: Increased risk of hypokalaemia

よくある質問