フルドロコルチゾン酢酸エステル

使用用途

• Maintenance therapy of hypoadrenocorticism
• Maintenance therapy of hypoadrenocorticism
• Hypoadrenocorticism
• Hypoadrenocorticism
• Maintenance of hypoadrenocorticism
• Hypoadrenocorticism

投与方法

考えられる副作用

• Polyuria (PU)
• Polydipsia (PD)
• Hypertension
• Edema
• Hypokalemia
• Hypernatremia
• Signs of iatrogenic Cushing's syndrome (due to glucocorticoid effects)

注意事項と禁忌

• Known hypersensitivity to fludrocortisone
• > **Stress Dosing:** All animals with hypoadrenocorticism should receive additional glucocorticoids (2-10 times basal dose) during periods of stress, surgery, or acute illness. * **Glucocorticoid Supplementation:** Some dogs or cats may require additional ongoing supplementation with a glucocorticoid agent (like prednisone) if fludrocortisone's inherent glucocorticoid activity is insufficient. * **Nursing Mothers:** May be excreted in significant quantities in milk. Puppies or kittens of treated mothers should receive milk replacer after colostrum is consumed. * **Cost:** Expense may be a limiting factor, especially in large breed dogs requiring high doses.

薬物相互作用

• Amphotericin B: Patients may develop hypokalemia if administered concomitantly.
• Aspirin: Fludrocortisone may reduce salicylate levels.
• Potassium-depleting diuretics (e.g., thiazides, furosemide): May cause hypokalemia; diuretics can cause sodium loss, counteracting the effects of fludrocortisone.
• Insulin: Potentially increases the insulin requirements of diabetic patients.

よくある質問