ジメルカプロール

使用用途

• Arsenic toxicity
• Arsenic toxicity
• Arsenic toxicity
• Arsenic toxicity
• Arsenic toxicity (no clinical signs)
• Arsenic toxicity (clinical signs)
• Arsenic, lead or mercury poisoning
• Mercury toxicity
• Arsenic toxicity
• Arsenic toxicity
• Mercury toxicity
• Arsenic toxicity
• Arsenic toxicity
• Arsenic toxicity

投与方法

考えられる副作用

• Pain at injection site
• Vomiting
• Seizures (at higher dosages)
• Transient increases in blood pressure
• Tachycardia
• Nephrotoxicity

注意事項と禁忌

• Impaired hepatic function (unless secondary to acute arsenic toxicity)
• Iron poisoning
• Cadmium poisoning
• Selenium poisoning
• Dimercaprol is potentially **nephrotoxic**; use cautiously in patients with impaired renal function. To protect the kidneys, the urine should be alkalinized to prevent the chelated drug from dissociating in the urine. Animals with diminished renal function or who develop renal dysfunction while on therapy should have the dosage adjusted or therapy discontinued. IM injections must be administered deeply to minimize pain. May decrease Iodine I 131 thyroidal uptake values.

薬物相互作用

• Iron: Forms a highly toxic complex. Do not administer with iron salts; wait at least 24 hours after the last dimercaprol dose before starting iron therapy.
• Selenium: Forms a highly toxic complex. Do not administer with selenium salts; wait at least 24 hours after the last dimercaprol dose before starting selenium therapy.
• Cadmium: Forms a highly toxic complex.
• Uranium: Forms a highly toxic complex.
• Iron supplements: Forms highly toxic complexes

よくある質問