クエン酸ジエチルカルバマジン

使用用途

• Treatment of ascarids
• Heartworm prophylaxis
• Treatment of early stages of Dictyocaulus viviparous infestations
• Heartworm prophylaxis
• Heartworm prophylaxis
• Heartworm prophylaxis
• Heartworm prophylaxis
• Treatment of ascarids
• Treatment of lungworms (Crenosoma vulpis)

投与方法

考えられる副作用

• Vomiting
• Diarrhea
• Fixed drug eruptions (rare)
• Severe anaphylactoid reaction (in microfilaremic dogs)
• Hepatic injury (reported in cats)

注意事項と禁忌

• Dogs with circulating microfilaria (due to risk of severe shock-like reaction)
• > **CRITICAL WARNING**: DEC is strictly contraindicated in dogs with circulating microfilariae. * Administration to microfilaremic dogs can trigger a severe, potentially fatal **anaphylactoid (shock-like) reaction** within 20 minutes to 2 hours. Signs include salivation, vomiting, ataxia, shock, and DIC. * Always verify a negative heartworm test (specifically checking for microfilaria) before initiating therapy. * If microfilaria are detected in dogs undergoing adulticide therapy while on DEC, stop DEC immediately until microfilaria are eliminated. * Rare reports of infertility in male dogs exist, though controlled studies show no adverse effects on semen.

薬物相互作用

• Pyrantel: Theoretical enhancement of toxic effects due to shared nicotine-like mechanism of action; use with intensified monitoring.
• Morantel: Theoretical enhancement of toxic effects due to shared nicotine-like mechanism of action; use with intensified monitoring.
• Levamisole: Theoretical enhancement of toxic effects due to shared nicotine-like mechanism of action; use with intensified monitoring.

よくある質問