オーロチオグルコース

投与方法

考えられる副作用

• Bone marrow suppression (thrombocytopenia, anemia, leukopenia)
• Nephrotoxicity (proteinuria, glomerulonephritis)
• Hepatotoxicity
• Stomatitis and oral ulcers
• Dermatologic reactions (Toxic epidermal necrolysis, Erythema multiforme)
• Anaphylaxis (rare)

注意事項と禁忌

• Pre-existing renal disease
• Hepatic dysfunction
• Severe hematologic disorders or pre-existing cytopenias
• Systemic lupus erythematosus (SLE)
• Pregnancy and lactation
• History of severe toxicity to heavy metals
• > **Strict Monitoring Required:** Requires strict monitoring of complete blood counts (CBC) and urinalysis prior to *every* injection due to the high risk of cumulative toxicity. Discontinue immediately if proteinuria, significant drop in platelet count, or leukopenia develops. Must be administered via deep intramuscular injection.

薬物相互作用

• Penicillamine: Increased risk of severe hematologic and renal toxicity.
• Immunosuppressants (e.g., cyclophosphamide, azathioprine): Synergistic bone marrow suppression; use together with extreme caution.
• Phenylbutazone: Increased risk of blood dyscrasias.

よくある質問