鋅 (醋酸鋅、硫酸鋅、葡萄糖酸鋅)

用途

• Adjunctive therapy of severe hepatic lipidosis
• Appetite stimulant
• Zinc-responsive dermatoses, copper storage disease
• Adjunctive treatment and prophylaxis of hepatic copper toxicosis
• Adjunctive treatment and prophylaxis of hepatic copper toxicosis
• Adjunctive treatment and prophylaxis of hepatic copper toxicosis
• Adjunctive treatment and prophylaxis of hepatic copper toxicosis
• Hepatic fibrosis
• Hepatic fibrosis
• Zinc-related dermatoses (Rapidly growing dogs)
• Zinc-responsive dermatoses (Siberian huskies, Alaskan malamutes, Great Danes, Doberman pinschers)
• Appetite stimulant

給藥方式

可能的副作用

• Gastrointestinal disturbances (vomiting, nausea, anorexia)
• Hematologic abnormalities (hemolytic anemia, particularly at serum levels >1000 mcg/dL)
• Hypotension (with overdose)
• Jaundice (with overdose)
• Pulmonary edema (with overdose)
• Nausea
• Vomiting
• Diarrhoea
• Haemolysis (at high doses)

注意事項與禁忌

• Patients with pre-existing copper deficiency
• Patients with copper deficiency
• Zinc supplementation should be carefully considered before administering to patients with copper deficiency. When dosing, do not confuse the concentrations of zinc salts with elemental zinc. Zinc overdoses (e.g., ingestion of U.S. pennies minted after 1982) can be highly toxic and potentially fatal, causing severe hemolytic anemia.

藥物相互作用

• Copper: Large doses of zinc inhibit copper absorption in the intestine; separate supplements by at least 2 hours.
• Fluoroquinolones (e.g., enrofloxacin, ciprofloxacin): Zinc salts may reduce the oral absorption of fluoroquinolones.
• Penicillamine: May potentially inhibit zinc absorption; clinical significance is not clear.
• Tetracyclines: Zinc salts may chelate oral tetracycline and reduce its absorption; separate doses by at least 2 hours.
• Ursodiol: May potentially inhibit zinc absorption; clinical significance is not clear.
• Iron: Long-term administration of zinc may lead to decreased iron stores and functional deficiency
• Ursodeoxycholic acid: May potentially inhibit zinc absorption
• Fluoroquinolones: Zinc salts may reduce the absorption of fluoroquinolone antibiotics

常見問題