硫普羅寧 (Tiopronin)

用途

• Prophylactic treatment of cystine urinary calculi
• Dissolution of uroliths
• In conjunction with an alkalinizing, protein and sodium restricted diet (e.g., u/d)
• Treatment of cystine urinary calculi
• Prevention of cystine urinary calculi

給藥方式

可能的副作用

• Coombs'-positive regenerative spherocyte anemia
• Aggressiveness
• Proteinuria
• Thrombocytopenia
• Elevations in liver enzymes and bile acids
• Dermatologic effects (small pustules, dry crusty nose, ecchymosis, itching, rashes, mouth ulcers, jaundice)
• Myopathy (staggering, difficulty chewing)
• Lethargy
• Sulfur odor of the urine
• GI distress
• Allergic reactions (adenopathy)
• Arthralgias
• Dyspnea
• Fever

注意事項與禁忌

• Agranulocytosis
• Aplastic anemia
• Thrombocytopenia or other significant hematologic abnormality
• Impaired renal or hepatic function
• Sensitivity to either tiopronin or penicillamine
• **Hematologic Toxicity:** Can cause severe blood dyscrasias. Use with extreme caution in patients with pre-existing hematologic abnormalities. **Immune-Mediated Reactions:** Associated with **Coombs'-positive regenerative spherocyte anemia** in dogs. If this occurs, discontinue immediately and initiate appropriate treatment (corticosteroids, blood component therapy). **Organ Impairment:** Use cautiously in patients with impaired renal or hepatic function. **Pregnancy/Nursing:** FDA Category C. Teratogenic effects (skeletal defects, cleft palates) and decreased fetus viability have been noted with related drugs (penicillamine) or at high doses. Not recommended for use in nursing animals as it may be excreted in milk.

藥物相互作用

• Nephrotoxic drugs: Potentially additive toxic effects
• Hepatotoxic drugs: Potentially additive toxic effects
• Bone marrow depressing drugs: Potentially additive toxic effects

常見問題