磺胺氯噠嗪鈉

用途

• Diarrhea caused or complicated by E. coli in calves less than one month of age
• Enteric bacterial infections (E. coli)
• Enteric bacterial infections (E. coli)
• E. coli and coccidiosis in pigeons
• Colibacillosis

給藥方式

可能的副作用

• Crystalluria
• Hematuria
• Renal tubule obstruction
• Keratoconjunctivitis sicca (KCS) in dogs
• Bone marrow depression
• Hypersensitivity reactions (rashes, dermatitis)
• Focal retinitis
• Fever
• Vomiting
• Nonseptic polyarthritis
• Muscle weakness, blindness, ataxia, and collapse (with rapid IV injection)
• Tissue irritation and necrosis (with IM or SC injection)
• Temporary depression of normal cellulytic function in the ruminoreticulum

注意事項與禁忌

• Hypersensitivity to sulfonamides, thiazides, or sulfonylurea agents
• Severe renal impairment
• Severe hepatic impairment
• > **Caution:** Use with care in patients with diminished renal or hepatic function, or urinary obstruction. * **Hydration:** Ensure adequate urine flow to prevent crystalluria. Alkalinization of urine may prevent crystalluria but decreases tubular reabsorption. * **Administration:** Avoid too-rapid IV injection to prevent acute neurological and muscular adverse effects. Avoid IM or SC routes due to the alkaline nature of the solution causing tissue irritation and necrosis. * **Pregnancy:** Potentially teratogenic at high doses; crosses the placenta. Weigh risk vs. benefit. * **Lactation:** Distributed into milk. Safe use during lactation cannot be assumed; use with caution. * **Laboratory:** May cause false-positive results for urine glucose determinations when using the Benedict's method.

藥物相互作用

• Antacids: May decrease the oral bioavailability of sulfonamides if administered concurrently

常見問題