氯解磷定 (Pralidoxime Chloride)

用途

• Organophosphate poisoning
• Organophosphate poisoning
• Organophosphate poisoning
• Organophosphate poisoning
• Organophosphate poisoning
• Organophosphate poisoning
• Organophosphate poisoning
• Organophosphate poisoning
• Organophosphate poisoning
• Organophosphate poisoning
• Organophosphate poisoning
• Organophosphate poisoning
• Organophosphate poisoning
• Organophosphate poisoning

給藥方式

可能的副作用

• Tachycardia (especially with rapid IV injection)
• Muscle rigidity
• Transient neuromuscular blockade
• Laryngospasm

注意事項與禁忌

• Hypersensitivity to pralidoxime
• Carbamate poisoning (generally not recommended as inhibition is rapidly reversible)
• Use with caution in patients receiving anticholinesterase agents for the treatment of myasthenia gravis, as it may precipitate a myasthenic crisis. Use cautiously and at a reduced dosage rate in patients with renal impairment. Must generally be given within 24 hours of exposure to be effective. Rapid IV injection should be avoided to prevent tachycardia, muscle rigidity, and laryngospasm.

藥物相互作用

• Barbiturates: Anticholinesterases can potentiate the action of barbiturates; use with caution.
• Cimetidine: Use should be avoided in patients with organophosphate toxicity.
• Succinylcholine: Use should be avoided in patients with organophosphate toxicity.
• Theophylline: Use should be avoided in patients with organophosphate toxicity.
• Reserpine: Use should be avoided in patients with organophosphate toxicity.
• Respiratory Depressants (e.g., narcotics, phenothiazines): Use should be avoided in patients with organophosphate toxicity.

常見問題