甲基睪酮

用途

• Anti-estrogenic activity, anabolic effects, negative feedback on gonadotropin release
• Alopecia X (when melatonin fails)
• Testosterone-responsive dermatosis
• Suppress estrus in Greyhounds
• Estrus suppression
• Anti-estrogenic activity, anabolic effects, negative feedback on gonadotropin release

給藥方式

可能的副作用

• Hepatotoxicity (elevated liver enzymes, icterus, periportal hepatocyte enlargement)
• Virilization of females (clitoral hypertrophy, vaginitis)
• Vaginal discharge
• Prostatic hyperplasia in males
• Increased aggression or behavioral changes
• Seborrhea
• Premature epiphyseal closure in young animals

注意事項與禁忌

• Hepatic dysfunction or pre-existing liver disease
• Pregnancy (Category X - causes fetal masculinization)
• Prostate cancer or severe prostatic hypertrophy
• ### Important Precautions * **Hepatotoxicity**: Chronic use is strongly associated with liver damage. Baseline and serial liver enzyme monitoring is mandatory. * **Cardiac Disease**: Use with extreme caution in patients with heart failure due to the potential for sodium and water retention. * **Growing Animals**: Prolonged use in young, growing animals can cause premature epiphyseal closure, stunting growth. * **Laboratory Interference**: Can decrease thyroxine-binding globulin, leading to decreased total T4 levels (free T4 remains unaffected).

藥物相互作用

• Cyclosporine: Methyltestosterone may increase serum cyclosporine levels, potentially leading to toxicity.
• Insulin: Methyltestosterone may decrease serum glucose levels, reducing insulin requirements.
• Oral Antidiabetic Agents: May decrease serum glucose levels, increasing the risk of hypoglycemia.
• Warfarin: Methyltestosterone may increase anticoagulant effects, increasing bleeding risk.

常見問題