銻酸甲胺
別名: Glucantime, Glucantim
藥物類別: Pentavalent Antimony Antileishmanial
* **治療期長且費用高**：請理解本藥物的療程通常相當漫長，且整體治療費用可能十分高昂。 * **無法完全治癒**：本藥物主要用於控制病情，極難達到「完全治癒」（徹底根除體內原蟲）的效果，復發是有可能的。 * **副作用觀察**：注射部位可能會出現腫脹或硬塊。若發現寵物出現食慾不振、嘔吐或極度疲倦，請立即聯繫獸醫師。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Leishmaniosis (off-label)
- Leishmaniasis (First line treatment)
- Leishmaniasis
- Leishmaniasis
- Leishmaniosis
給藥方式
SCIM
可能的副作用
- Injection site reactions (cutaneous abscesses, cellulitis, pain)
- Lethargy
- Gastrointestinal effects (inappetence, vomiting)
- Transient increases in liver enzymes
- Nephrotoxicity (tubular damage, proximal tubule cell vacuolization, coagulative necrosis)
- Pain and swelling at the injection site
- Nephrotoxicity (proteinuria, elevated BUN/creatinine)
- Anorexia
- Vomiting
- Hepatotoxicity (rare)
- Myalgia/arthralgia
注意事項與禁忌
- Previous hypersensitivity to meglumine antimoniate
- Severe renal, hepatic, or cardiac failure (relative contraindication; weigh risks vs. benefits)
- Severe renal impairment
- Hepatic failure
- Cardiac disease
- **Extreme caution** is advised in patients with pre-existing **renal, hepatic, or cardiac insufficiency**. * **Renal Impairment**: Decreased renal function can lead to significant drug accumulation and an increased risk of severe toxicity. In dogs with severe renal failure (IRIS stages III-IV), correction of fluid and acid-base imbalances prior to treatment with allopurinol alone is recommended before considering antimonials. * **Hypersensitivity**: Hypersensitivity reactions have been reported in humans; avoid in patients with known allergies to the drug. * **Pregnancy**: Teratogenic effects (fetal resorptions, bone abnormalities) have been noted in animal models. Weigh risks versus benefits carefully.
藥物相互作用
- Agents that can prolong QT interval (e.g., tricyclic antidepressants, disopyramide, quinidine, procainamide): Meglumine antimoniate may prolong QT interval further with increased risk for arrhythmias
- Aminoglycosides: Increased risk of nephrotoxicity
- NSAIDs: Increased risk of nephrotoxicity
常見問題
銻酸甲胺用於寵物有什麼用途？
• 治療期長且費用高：請理解本藥物的療程通常相當漫長，且整體治療費用可能十分高昂。 • 無法完全治癒：本藥物主要用於控制病情，極難達到「完全治癒」（徹底根除體內原蟲）的效果，復發是有可能的。 • 副作用觀察：注射部位可能會出現腫脹或硬塊。若發現寵物出現食慾不振、嘔吐或極度疲倦，請立即聯繫獸醫師。
銻酸甲胺對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。