左旋甲狀腺素鈉

用途

• Hypothyroidism
• Post thyroidectomy
• Hypothyroidism
• Adjunctive treatment of equine metabolic syndrome
• Hypothyroidism
• Hypothyroidism
• Hypothyroidism
• Hypothyroidism
• Myxedema coma
• Hypothyroidism in tortoises

給藥方式

可能的副作用

• Tachycardia
• Polyphagia
• Polyuria/Polydipsia (PU/PD)
• Excitability
• Nervousness
• Excessive panting
• Apathy or listlessness (seen in some cats)

注意事項與禁忌

• Acute myocardial infarction
• Thyrotoxicosis
• Untreated adrenal insufficiency
• Use with caution and at a lower initial dosage in patients with concurrent hypoadrenocorticism (treated), cardiac disease, diabetes, or in elderly patients. High fiber diets may reduce absorption. Hypothyroid dogs can have decreased GFR; restoration to a euthyroid state can increase GFR and reduce serum creatinine levels. Numerous drugs can affect thyroid function tests (T4, T3, TSH), so evaluate lab results accordingly.

藥物相互作用

• Amiodarone: May decrease the metabolism of T4 to T3
• Antacids, Oral: May reduce levothyroxine absorption; separate doses by 4 hours
• Antidepressants, Tricyclic/Tetracyclic: Increased risk for CNS stimulation and cardiac arrhythmias
• Antidiabetic Agents (insulin, oral agents): Levothyroxine may increase requirements for insulin or oral agents
• Cholestyramine: May reduce levothyroxine absorption; separate doses by 4 hours
• Corticosteroids (high dose): Decreased conversion of T4 to T3
• Digoxin: Potential for reduced digoxin levels
• Ferrous Sulfate: May reduce levothyroxine absorption; separate doses by 4 hours
• Ketamine: May cause tachycardia and hypertension
• Phenobarbital: Possible increased metabolism of thyroxine; dosage adjustments may be needed
• Propylthiouracil: Decreased conversion of T4 to T3

常見問題