碘泊酸鈉

用途

• Medical treatment of hyperthyroidism in patients who cannot tolerate methimazole and whose owners will not permit surgery or radioiodine therapy
• Medical treatment of hyperthyroidism in patients who cannot tolerate methimazole and whose owners will not permit surgery or radioiodine therapy
• For use before surgery

給藥方式

可能的副作用

• GI distress (nausea, vomiting, diarrhea, cramping, inappetence)
• Transient efficacy (patients may become refractory)
• Drug-induced pemphigus (rare)
• Skin rashes, itching, dizziness, and headache (reported in humans)

注意事項與禁忌

• Known hypersensitivity to ipodate or other iodine compounds
• Pregnancy (risk of congenital hypothyroidism in fetuses)
• Use with caution in patients who have had previous hypersensitivity reactions to iodine compounds. In humans, multiple doses are contraindicated in patients with hepatic dysfunction due to reports of renal toxicity. Use with caution in patients with hyperuricemia due to the possibility of uric acid nephropathy. **Laboratory Interferences:** * May increase BSP retention times and serum bilirubin levels. * May cause false-positive urine protein determinations. * Interferes with thyroid scanning.

藥物相互作用

• Radioactive Iodine (I-131): Ipodate may interfere with radioactive iodine uptake and therapy. It is recommended to discontinue ipodate at least 2 weeks (preferably 3-4 weeks or more) prior to I-131 treatment.

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