丙酸氟替卡松

用途

• Treatment of feline 'asthma'
• Feline asthma (signs occurring more than once per week)
• Inflammatory airway disease (IAD) in young racehorses
• Moderate recurrent airway obstruction (RAO/heaves)
• Prevention of exacerbations of RAO
• Adjunctive treatment of chronic tracheobronchial disease (excessive side effects from oral steroids)
• Adjunctive treatment of chronic tracheobronchial disease

給藥方式

可能的副作用

• Pharyngitis (reported in humans)
• Upper respiratory infections (reported in humans)
• Hypothalamic-pituitary-adrenal (HPA) axis suppression (rare with inhaled therapy, but possible with chronic high doses)
• Cushingoid effects (with chronic overdosage)
• Paradoxical bronchospasm (rare)

注意事項與禁忌

• Hypersensitivity to fluticasone
• Acute bronchospasm or status asthmaticus (not a rescue inhaler)
• When transferring patients from systemic steroid therapy to inhaled steroids, wean slowly off systemic therapy to avoid acute adrenal insufficiency. Prepare to cover patients with additional systemic steroid therapy during periods of acute stress, severe asthma attacks occurring during the withdrawal stage, or after transfer to inhaled steroids. Fluticasone is not useful for acute bronchospasm. Use with caution in nursing dams. FDA Category C for pregnancy; use only when benefits clearly outweigh risks.

藥物相互作用

• Ketoconazole: Inhibits CYP3A4 isoenzymes; theoretically could increase systemic fluticasone levels.
• Other CYP3A4 inhibitors: May decrease the metabolism of fluticasone, potentially increasing systemic exposure.

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