氯苯那敏

用途

• General antihistamine use
• General antihistamine use
• General antihistamine use
• Pruritus
• Pruritus
• Mild sedative
• General antihistamine use
• General use / Feather damaging behavior
• Adjunctive treatment of chemotherapy of mast cell tumors
• General antihistamine use
• General antihistamine use
• Trial for pruritus in atopic dogs
• Pruritus
• Mild sedative

給藥方式

可能的副作用

• CNS depression (lethargy, somnolence, sedation)
• GI effects (diarrhea, vomiting, anorexia)
• Anticholinergic effects (dry mouth, urinary retention)
• Paradoxical excitement (especially in cats)
• Decreased performance in working dogs due to sedation

注意事項與禁忌

• Hypersensitivity to chlorpheniramine or other alkylamine antihistamines
• ### Warnings and Precautions * **Anticholinergic Effects:** Use with caution in patients with **angle closure glaucoma**, **prostatic hypertrophy**, **pyloroduodenal or bladder neck obstruction**, and **COPD** (if mucosal secretions are a problem). * **Systemic Disease:** Use cautiously in patients with **hyperthyroidism**, **cardiovascular disease**, or **hypertension**. * **Working Dogs:** Sedative effects may adversely affect the performance of working dogs. * **Laboratory Testing:** Antihistamines can decrease the wheal and flare response to antigen skin testing. It is generally recommended to discontinue antihistamines at least 4 days prior to intradermal allergy testing. * **Nursing/Pregnancy:** FDA Category B in humans. It is unknown if it is excreted in milk; use with caution in nursing dams.

藥物相互作用

• Anticoagulants (heparin, warfarin): Antihistamines may partially counteract the anticoagulation effects of heparin or warfarin.
• MAO Inhibitors (amitraz, selegiline): May prolong and exacerbate the anticholinergic effects of the antihistamine.
• CNS Depressants: Increased sedation and CNS depression can occur when used concurrently.
• CNS Depressants (e.g., opioids, sedatives, barbiturates): Additive CNS depression and sedation
• Anticholinergic drugs: Additive anticholinergic effects (dry mouth, tachycardia, urinary retention)

常見問題