布比卡因

用途

• Regional, epidural, perineural, or intrapleural analgesia
• Regional, epidural, perineural, or intrapleural analgesia

給藥方式

可能的副作用

• Severe cardiac arrhythmias (if injected intravascularly)
• Motor blockade (paresis/paralysis of affected limbs)
• CNS toxicity (seizures, tremors) at high systemic doses
• Hypotension (especially with epidural use)

注意事項與禁忌

• Intravenous (IV) administration
• Intravenous regional anaesthesia (Bier block)
• Use of adrenaline-containing formulations at end-arterial sites (e.g., tail, digits, ears)
• Use of adrenaline-containing formulations when significant systemic absorption is likely
• > **CRITICAL WARNING:** Inadvertent intravascular injection may precipitate severe cardiac arrhythmias that are refractory to standard resuscitation treatments. Always aspirate prior to injection. * Lower doses should be used when systemic absorption is likely to be high (e.g., intrapleural analgesia). * Normal sterile precautions should be observed during administration.

藥物相互作用

• Other local anaesthetics (e.g., lidocaine, mepivacaine): Additive systemic toxicity; doses must be reduced when used concurrently.

常見問題