白蛋白（人源與犬源）

用途

• Refractory hypotension or severe hypoalbuminemia (using 25% Human Albumin)
• Marked hypoalbuminemia (using 10% Human Albumin)
• Hypovolemic shock or hypoalbuminemia (using Canine Albumin 5g lyophilized)

給藥方式

可能的副作用

• Immediate hypersensitivity (anaphylaxis, facial edema, vomiting, urticaria, hyperthermia, shock)
• Delayed hypersensitivity / Type III serum sickness (lethargy, lameness, peripheral edema, cutaneous lesions/vasculitis, renal failure, coagulopathies)
• Volume overload
• Diarrhea
• Tremors
• Perivascular inflammation at catheter sites

注意事項與禁忌

• History of hypersensitivity to albumin (human or canine)
• Repeat administration of xeno-albumin (human albumin in dogs) beyond 7 days
• Healthy animals with simple volume depletion (avoid xeno-albumin)
• Pre-existing conditions resulting in volume overload
• Severe anemia or extreme dehydration (unless concurrent RBCs or appropriate crystalloid fluids are administered first)
• **Extreme Caution Required:** Thoughtful consideration must be taken when deciding to administer human albumin to critically ill dogs due to the high risk of complications. * **Hypersensitivity:** Both immediate (anaphylactoid) and delayed (Type III/serum sickness) reactions can occur and have been fatal. * **Monitoring:** Frequent monitoring of vital signs, oncotic pressure, and albumin levels is mandatory. * **Infectious Agents:** While risk is low, transmission of infectious agents from pooled albumin products is theoretically possible.

藥物相互作用

• Highly protein-bound drugs: Exogenous albumin may bind to these drugs, potentially affecting the amount of free (active) drug circulating, though this rarely appears to be clinically significant.

常見問題