Sertraline
別名: Zoloft, Altruline, Anilar, Aremis, Atenix, Besitran, Bicromil, Gladem, Insertec, Irradial, Lustral, Novativ, Sealdin, Serad, Sercerin, Serlain, Serta, Tatig, Tolrest, Tresleen
**What to Expect:** * **Patience is Key:** This medication does not work immediately. It typically takes **4 to 8 weeks** of consistent daily dosing to see noticeable improvements in your pet's behavior. * **Commitment:** You must commit to using the drug for several months to accurately determine if it is helping. **Important Guidelines:** * **Do Not Stop Abruptly:** Never suddenly stop giving this medication unless directed by your veterinarian, as it can cause withdrawal symptoms. If the medication needs to be stopped, your vet will provide a tapering schedule. * **Appetite Changes:** A decrease in appetite is common, especially in dogs, when starting the medication. This is usually temporary. You can try hand-feeding or making the food more palatable. If your pet stops eating entirely, contact your vet. * **Monitor Behavior:** Because this drug alters brain chemistry, watch for any unusual behavior, such as increased anxiety, restlessness, or unexpected aggression. Report any significant abnormal findings to your veterinarian immediately. * **Liquid Medication:** If using the oral solution, it must be diluted before giving it to your pet. Only mix it with water, orange juice, ginger ale, lemonade, or lemon/lime soda, and give it immediately after mixing.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Treatment of compulsive disorders
- Urine marking (spraying), aggression, anxiety-including anxiogenic house soiling, phobias, fears
- Treatment of behavioral diagnoses
- Treatment of fear, affective or dominance aggression
- Generalized anxiety disorder
- Treatment of compulsive disorder, anxiety
- Behavioral diagnoses
- Increase inhibitory control (e.g., play-related aggressive behaviour)
- Treatment of compulsive disorders
- Behavioral diagnoses
- Behavioral diagnoses
- Treatment of behavioral diagnoses
- Compulsive disorder, anxiety
給藥方式
可能的副作用
- Anorexia (common in dogs, usually transient)
- Lethargy or sedation
- Gastrointestinal effects (vomiting, diarrhea)
- Anxiety or irritability
- Insomnia or hyperactivity
- Panting (dogs)
- Changes in elimination patterns (cats)
- Paradoxical aggressive behavior in previously non-aggressive animals
- Lethargy
- Decreased appetite
- Vomiting
- Trembling
- Restlessness
- Gastrointestinal disturbance
注意事項與禁忌
- Known hypersensitivity to sertraline or other SSRIs
- Concurrent use of Monoamine Oxidase Inhibitors (MAOIs) such as selegiline or amitraz
- Concurrent use of cisapride
- History of seizures or epilepsy
- Concurrent use of MAOIs (e.g., selegiline)
- **Hepatic Impairment:** Use with caution in patients with severe hepatic disease; dosages may need to be decreased or the dosing interval increased due to extensive hepatic metabolism. **Geriatric Patients:** Use with caution; dose adjustments may be necessary. **Pregnancy:** FDA Category C in humans. Animal studies (rats/rabbits) showed delayed ossification and decreased pup survival. Use only if benefits outweigh risks. **Weaning:** Avoid abrupt discontinuation; taper the dose gradually over several weeks to prevent withdrawal signs.
藥物相互作用
- Buspirone: Increased risk for serotonin syndrome
- Cimetidine: May increase sertraline levels
- Cyproheptadine: May decrease or reverse the effects of SSRIs
- Diazepam: Sertraline may decrease diazepam clearance
- Isoniazid: Increased risk for serotonin syndrome
- MAO Inhibitors (e.g., amitraz, selegiline): High risk for serotonin syndrome; use contraindicated. A 5-week washout period is required after discontinuing sertraline before starting an MAOI, and a 2-week washout if discontinuing an MAOI before starting sertraline.
- Pentazocine: Serotonin syndrome-like adverse effects possible
- Tramadol: SSRIs can inhibit the metabolism of tramadol to active metabolites, decreasing efficacy and increasing the risk of toxicity (serotonin syndrome, seizures)
- Tricyclic Antidepressants (e.g., clomipramine, amitriptyline): Sertraline may increase TCA blood levels and increase the risk for serotonin syndrome
- Warfarin: Sertraline may increase the risk for bleeding
常見問題
Sertraline用於寵物有甚麼用途？
**What to Expect:** * **Patience is Key:** This medication does not work immediately. It typically takes **4 to 8 weeks** of consistent daily dosing to see noticeable improvements in your pet's behavior. * **Commitment:** You must commit to using the drug for several months to accurately determine if it is helping. **Important Guidelines:** * **Do Not Stop Abruptly:** Never suddenly stop giving this medication unless directed by your veterinarian, as it can cause withdrawal symptoms. If the medication needs to be stopped, your vet will provide a tapering schedule. * **Appetite Changes:** A decrease in appetite is common, especially in dogs, when starting the medication. This is usually temporary. You can try hand-feeding or making the food more palatable. If your pet stops eating entirely, contact your vet. * **Monitor Behavior:** Because this drug alters brain chemistry, watch for any unusual behavior, such as increased anxiety, restlessness, or unexpected aggression. Report any significant abnormal findings to your veterinarian immediately. * **Liquid Medication:** If using the oral solution, it must be diluted before giving it to your pet. Only mix it with water, orange juice, ginger ale, lemonade, or lemon/lime soda, and give it immediately after mixing.
Sertraline對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。