Piperacillin Sodium + Tazobactam
別名: Zosyn, Tazobac, Tazocin
> **Note:** This medication is typically reserved for hospitalized pets with severe infections. * **Administration**: Given by your veterinarian as an intravenous (IV) or intramuscular (IM) injection. * **Safety**: Generally very safe, but let your veterinarian know if your pet has ever had an allergic reaction to penicillin or other antibiotics. * **Side Effects**: May cause mild stomach upset or diarrhea. Severe side effects are rare but can include neurological signs at extremely high doses.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Single-agent therapy of intra-abdominal sepsis
- Susceptible infections
- Severe polymicrobic bacteremia
- Preoperative orthopedic or coelomic surgery
- Single-agent therapy of intra-abdominal sepsis
- Bacterial sepsis
- Life-threatening infections (e.g., Pseudomonas)
- Life-threatening infections
給藥方式
可能的副作用
- Hypersensitivity reactions
- Local effects (thrombophlebitis) associated with IV injection
- Antibiotic-associated diarrhea (alterations in gut flora)
- Coagulation abnormalities (rare, particularly in renal failure)
- Neurotoxicity/seizures (at very high doses, especially with diminished renal function)
- Clostridium difficile superinfections (rare)
- Nausea
- Diarrhoea
- Skin rashes
- Pain on intramuscular injection
- Sodium overload (in susceptible patients)
注意事項與禁忌
- Patients with documented hypersensitive reactions to a beta-lactam or beta-lactamase inhibitor
- Known hypersensitivity to penicillins or cephalosporins
- > **High Sodium Content:** High dosages may adversely affect patients with cardiac failure or hypernatremic conditions. * **Renal Impairment:** Dosage adjustment may be required in patients with significantly decreased renal function (CrCl <40 mL/min). * **Laboratory Interference:** May cause false-positive results for urine glucose (cupric sulfate methods like Clinitest), direct antiglobulin (Coombs') tests, and urine protein (sulfosalicylic acid, boiling, nitric acid, or acetic acid tests). May also falsely decrease aminoglycoside serum quantitative analysis if samples are stored prior to analysis.
藥物相互作用
- Aminoglycosides (amikacin, gentamicin, tobramycin): Synergistic or additive activity against certain bacteria. However, penicillins can inactivate aminoglycosides in vitro and in vivo in patients in renal failure or at massive dosages. Amikacin is the most resistant to this inactivation.
- Anticoagulants (heparin, warfarin): Piperacillin may rarely affect platelets; increased monitoring of coagulation parameters is suggested.
- Methotrexate: Piperacillin may increase MTX serum levels.
- Probenecid: Can reduce the renal tubular secretion of both piperacillin and tazobactam, maintaining higher systemic levels for a longer period.
- Vecuronium: Piperacillin may prolong neuromuscular blockade.
- Non-depolarizing muscle relaxants: Piperacillin enhances the effects of non-depolarizing muscle relaxants.
- Gentamicin: Inactivates piperacillin if mixed in the same syringe.
- Aminoglycosides: Synergistic bactericidal effect against pseudomonal septicaemias when administered systemically (not mixed in vitro).
常見問題
Piperacillin Sodium + Tazobactam用於寵物有甚麼用途？
> **Note:** This medication is typically reserved for hospitalized pets with severe infections. * **Administration**: Given by your veterinarian as an intravenous (IV) or intramuscular (IM) injection. * **Safety**: Generally very safe, but let your veterinarian know if your pet has ever had an allergic reaction to penicillin or other antibiotics. * **Side Effects**: May cause mild stomach upset or diarrhea. Severe side effects are rare but can include neurological signs at extremely high doses.
Piperacillin Sodium + Tazobactam對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。