Paroxetine
別名: Paxil, Paxil CR, Pexeva, Seroxat
* **Patience is Key**: Behavioral medications like paroxetine can take several weeks (often 4-8 weeks) to show full effects. Do not stop the medication abruptly unless directed by your veterinarian. * **Administration**: Can be given with or without food. If your pet experiences stomach upset, giving it with a small treat or meal may help. * **Side Effects**: Watch for changes in appetite (eating less is common initially), lethargy, or gastrointestinal upset. In cats, monitor closely for constipation or changes in litter box habits. * **Safety**: Keep medication strictly out of reach of children and other pets. **Never** give your pet human medications without veterinary approval, as dosages differ significantly.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- SSRI responsive behavior problems
- Compulsive disorders
- Generalized anxiety disorder
- Marking
- Intercat aggression
- SSRI responsive behavior problems
- Urine marking (especially with overt aggression)
- Compulsive disorders
- Generalized anxiety disorder
- Adjunctive treatment of phobias, fears, and anxieties
- Generalized anxiety and impulsivity
給藥方式
可能的副作用
- Anorexia (common, usually transient)
- Lethargy
- GI effects
- Anxiety
- Irritability
- Insomnia/hyperactivity
- Panting
- Aggressive behavior in previously unaggressive dogs
- Constipation (especially in cats)
- Changes in elimination patterns
- Changes in blood glucose levels
- Reduced seizure threshold
- Decreased appetite
- Vomiting
注意事項與禁忌
- Patients with known hypersensitivity to paroxetine
- Patients receiving monoamine oxidase inhibitors (MAOIs)
- Known hypersensitivity to paroxetine or other SSRIs
- History of seizures or epilepsy
- Concurrent use of Monoamine Oxidase Inhibitors (MAOIs)
- Concurrent use of other serotonergic agents (due to serotonin syndrome risk)
- Use with caution in patients with **seizure disorders**, or **severe cardiac, hepatic, or renal disease**. Dosages may need to be reduced in patients with severe hepatic or renal impairment. If paroxetine is rapidly discontinued, withdrawal reactions can occur. If the patient has been receiving the drug for an extended period, a **gradual withdrawal** is recommended. Safety during pregnancy has not been established (FDA Category C in humans); use caution in nursing patients as the drug is excreted into milk at low levels.
藥物相互作用
- Buspirone: Increased risk for serotonin syndrome
- Cimetidine: May increase paroxetine levels
- Cyproheptadine: May decrease or reverse the effects of SSRIs
- Digoxin: Paroxetine (in humans) can decrease digoxin AUC by 15%
- Insulin: May alter insulin requirements
- Isoniazid: Increased risk for serotonin syndrome
- MAO Inhibitors (including amitraz and selegiline): High risk for serotonin syndrome; use contraindicated. A 5-week washout period is required after discontinuing paroxetine, and a 2-week washout if discontinuing the MAOI first.
- Pentazocine: Serotonin syndrome-like adverse effects possible
- Phenobarbital: May decrease paroxetine levels
- Phenytoin: Increased plasma levels of phenytoin possible; may decrease paroxetine levels
- Propranolol, Metoprolol: Paroxetine may increase these beta-blockers' plasma levels and cause hypotension; atenolol may be safer
常見問題
Paroxetine用於寵物有甚麼用途？
* **Patience is Key**: Behavioral medications like paroxetine can take several weeks (often 4-8 weeks) to show full effects. Do not stop the medication abruptly unless directed by your veterinarian. * **Administration**: Can be given with or without food. If your pet experiences stomach upset, giving it with a small treat or meal may help. * **Side Effects**: Watch for changes in appetite (eating less is common initially), lethargy, or gastrointestinal upset. In cats, monitor closely for constipation or changes in litter box habits. * **Safety**: Keep medication strictly out of reach of children and other pets. **Never** give your pet human medications without veterinary approval, as dosages differ significantly.
Paroxetine對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。