Pamidronate Disodium
別名: Aredia, Aminomux, Aredronet, Ostepam, Pamidran
**Information for Pet Owners:** * **Hospitalization Required**: This medication must be given in a veterinary hospital setting. It is administered as a very slow intravenous (IV) drip, usually over 2 to 4 hours, to protect your pet's kidneys. * **Purpose**: Pamidronate is highly effective at lowering dangerously high blood calcium levels (often caused by certain cancers or toxins) and can significantly relieve severe bone pain associated with bone tumors (like osteosarcoma). * **Monitoring**: Your veterinarian will need to run blood and urine tests before each treatment to ensure your pet's kidneys are functioning well and to check electrolyte levels (like calcium and magnesium). * **Cost**: Because this is a specialized human hospital drug requiring intensive monitoring and slow IV administration, clients should be prepared for the associated costs of the medication and the required inpatient care.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Control of hypercalcemia
- Refractory hypercalcemia
- Control of hypercalcemia
- Treatment of cholecalciferol-induced toxicosis
- Attempting to reduce bone pain associated with osteosarcoma in combination with an NSAID
- Pain associated with skeletal neoplasias
- Calcipotriene toxicosis
- Control of hypercalcemia
給藥方式
可能的副作用
- Electrolyte abnormalities (hypomagnesemia, hypocalcemia, hypophosphatemia)
- Cardiac arrhythmias (secondary to electrolyte shifts)
- Renal toxicity (especially with rapid infusion)
- Transient bone pain
- Anemia
- Thrombocytopenia
- Granulocytosis
- Ophthalmic syndromes (e.g., scleritis - reported in humans)
注意事項與禁忌
- Hypersensitivity to pamidronate or other bisphosphonates
- Severe renal impairment (use with extreme caution; not tested in humans with serum creatinine > 5 mg/dL)
- **Important Warnings and Precautions:** * **Renal Toxicity**: Pamidronate can cause acute renal failure. The risk is minimized by ensuring adequate patient hydration and infusing the drug slowly over at least 2 to 4 hours. * **Fluid Compatibility**: **Do NOT mix** with any intravenous fluid containing calcium (e.g., Lactated Ringer's). Must be diluted in 0.9% NaCl, 0.45% NaCl, or D5W. * **Pregnancy**: FDA Category D. Has produced maternal and embryo/fetal toxicity in laboratory animals. Use only if benefits outweigh risks, with informed owner consent. * **Nursing**: Unknown if excreted in milk; use with caution. * **Electrolyte Shifts**: Can cause profound hypocalcemia and hypomagnesemia. Baseline and post-infusion monitoring is critical.
藥物相互作用
- Calcium-affecting drugs (e.g., furosemide, corticosteroids): Can affect calcium levels; requires careful monitoring when used concurrently.
- Nephrotoxic drugs (e.g., cisplatin, aminoglycosides): Potential for increased risk of nephrotoxicity; use with caution.
常見問題
Pamidronate Disodium用於寵物有甚麼用途？
**Information for Pet Owners:** * **Hospitalization Required**: This medication must be given in a veterinary hospital setting. It is administered as a very slow intravenous (IV) drip, usually over 2 to 4 hours, to protect your pet's kidneys. * **Purpose**: Pamidronate is highly effective at lowering dangerously high blood calcium levels (often caused by certain cancers or toxins) and can significantly relieve severe bone pain associated with bone tumors (like osteosarcoma). * **Monitoring**: Your veterinarian will need to run blood and urine tests before each treatment to ensure your pet's kidneys are functioning well and to check electrolyte levels (like calcium and magnesium). * **Cost**: Because this is a specialized human hospital drug requiring intensive monitoring and slow IV administration, clients should be prepared for the associated costs of the medication and the required inpatient care.
Pamidronate Disodium對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。