Leucovorin Calcium
別名: Folinic acid, Citrovorum factor
> **Important**: If this medication is being used to treat methotrexate toxicity, it should only be administered in an inpatient hospital setting under strict veterinary supervision. * **Administration**: Oral leucovorin may be given with or without meals. * **Strict Adherence**: It is critical to follow the exact dosage schedule prescribed by your veterinarian. Missing doses can compromise the treatment or prevention of severe blood cell abnormalities (hematologic toxicity). * **Missed Doses**: If you miss a dose, contact your veterinarian for instructions. Do not double up on doses without professional guidance.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Folate deficiency associated with pyrimethamine use
- Bone marrow suppression associated with pyrimethamine or trimethoprim/sulfa
- To prevent bone marrow toxicity associated with pyrimethamine
- Methotrexate overdose
- Macrocytic anemia and neutropenia associated with pyrimethamine and/or trimethoprim (especially in pregnant mares)
- Folate deficiency associated with pyrimethamine use
- Methotrexate overdose
給藥方式
可能的副作用
- Gastrointestinal effects (noted in humans with oral administration)
- Seizures (very rare, noted in humans)
- Hypersensitivity reactions (very rare, noted in humans)
注意事項與禁忌
- Known intolerance or hypersensitivity to leucovorin
- Use with extreme caution in patients receiving systemic fluorouracil. Because of its calcium content, large intravenous doses should be given slowly and not bolused. In humans, folinic acid therapy may mask the signs associated with cobalamin (B-12) deficiency in megaloblastic anemias. When reconstituting powder with bacteriostatic water (which contains benzyl alcohol), avoid use in neonates or very small animals.
藥物相互作用
- Barbiturates, Primidone, Phenytoin: Large doses of leucovorin may reduce the antiseizure efficacy of these agents.
- Fluorouracil (5-FU): Leucovorin may increase both the antineoplastic efficacy and toxicity of 5-FU.
- Trimethoprim, Ormetoprim, Pyrimethamine: Leucovorin may reduce their efficacy somewhat; however, protozoa cannot utilize leucovorin, preserving the antimicrobial effect against them.
常見問題
Leucovorin Calcium用於寵物有甚麼用途？
> **Important**: If this medication is being used to treat methotrexate toxicity, it should only be administered in an inpatient hospital setting under strict veterinary supervision. * **Administration**: Oral leucovorin may be given with or without meals. * **Strict Adherence**: It is critical to follow the exact dosage schedule prescribed by your veterinarian. Missing doses can compromise the treatment or prevention of severe blood cell abnormalities (hematologic toxicity). * **Missed Doses**: If you miss a dose, contact your veterinarian for instructions. Do not double up on doses without professional guidance.
Leucovorin Calcium對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。