Immune Globulin (Human), Intravenous (IVIG)
別名: IVIG, hIVIG, IGIV, Felbogamma, Octagam, Gammaplex, Gamunex, Gammagard, Privigen, Carimune NF
**Important Information for Pet Owners:** * **What it is:** IVIG is a highly specialized human blood product made of concentrated antibodies. It is used as a "last resort" treatment for severe autoimmune diseases where the pet's immune system is attacking its own body. * **Cost:** This medication is **extremely expensive** (often thousands of dollars for a single treatment) because it is derived from human plasma donors. * **Risks:** Because it is a human protein, there is a risk of allergic reactions (including severe anaphylaxis) in dogs. It can also cause fluid overload or, rarely, kidney issues or blood clots. * **Expectations:** It is given as a very slow intravenous (IV) drip in the hospital, usually over 6 to 12 hours. While it can be life-saving, results are not guaranteed, and it is usually reserved for pets that have failed all other standard therapies.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Immune-mediated diseases (IMHA, ITP) - General
- IMHA (refractory to conventional treatment)
- Primary immune-mediated thrombocytopenia (pIMT)
- Refractory erythema multiforme, Stevens-Johnson syndrome/toxic epidermal necrolysis, and other cutaneous adverse drug reactions
給藥方式
可能的副作用
- Increased blood pressure
- Local injection site reactions (pain, tenderness)
- Anaphylaxis / Hypersensitivity reactions
- Volume overload (due to colloid-like properties)
- Thrombotic events
- Fever, chills, facial flushing, nausea (human data)
- Renal dysfunction / Acute renal failure (human data)
注意事項與禁忌
- Prior hypersensitivity reactions to human albumin or human blood products
- > **BLACK BOX WARNING (Human Label):** IVIG has been associated with renal dysfunction, acute renal failure, osmotic nephrosis, and death in humans. * **Hypersensitivity:** IVIG contains trace amounts of human albumin, which can trigger severe hypersensitivity or anaphylaxis in dogs, especially upon repeated exposure. * **Infusion Rates:** Adverse reactions are strongly associated with rapid infusion. Must be infused slowly (typically over a 6-12 hour period in dogs). * **Volume Overload:** IVIG has colloid-like properties; use with caution in patients with compromised cardiac or renal function. * **Laboratory Interference:** * *Blood Glucose:* Can cause falsely elevated readings on glucose dehydrogenase pyrroloquinoline quinone (GDH-PQQ) based monitors. Use glucose oxidase or other unaffected methods. * *Coombs Test:* Passively transferred antibodies may cause false-positive serological test results.
藥物相互作用
- Live Vaccines: IVIG may interfere with the immune response and efficacy of the vaccine due to passively transferred antibodies.
常見問題
Immune Globulin (Human), Intravenous (IVIG)用於寵物有甚麼用途？
**Important Information for Pet Owners:** * **What it is:** IVIG is a highly specialized human blood product made of concentrated antibodies. It is used as a "last resort" treatment for severe autoimmune diseases where the pet's immune system is attacking its own body. * **Cost:** This medication is **extremely expensive** (often thousands of dollars for a single treatment) because it is derived from human plasma donors. * **Risks:** Because it is a human protein, there is a risk of allergic reactions (including severe anaphylaxis) in dogs. It can also cause fluid overload or, rarely, kidney issues or blood clots. * **Expectations:** It is given as a very slow intravenous (IV) drip in the hospital, usually over 6 to 12 hours. While it can be life-saving, results are not guaranteed, and it is usually reserved for pets that have failed all other standard therapies.
Immune Globulin (Human), Intravenous (IVIG)對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。