Imipramine
別名: Tofranil, Tofranil-PM
- **Patience is Key**: Behavioral changes may take **several weeks** to become noticeable. Continue dosing as prescribed and do not stop the medication abruptly without consulting your veterinarian. - **Safety First**: This medication is **highly toxic in overdose** to both animals and humans. Keep it in child-resistant packaging, securely locked away from pets and children. - **Side Effects**: You may notice your pet becoming sleepy, having a dry mouth, or experiencing constipation. If your pet seems overly excited, trembles, or has a seizure, contact your vet immediately. - **Missed Doses**: If you miss a dose, give it when you remember, but never double up on doses.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Urethral incompetence
- Adjunctive cancer pain treatment
- Anxiety, inappropriate urination
- Pharmacologic induced ejaculation
- Narcolepsy/cataplexy
- Urethral incompetence
- Urinary incontinence when other agents fail
- Cataplexy
- Adjunctive treatment of separation anxiety or other tricyclic antidepressant-responsive behavior disorders
- Adjunctive cancer pain treatment
- Anxiety, inappropriate urination, narcolepsy
- Anxiety, inappropriate urination, narcolepsy
給藥方式
可能的副作用
- Sedation
- Dry mouth
- Constipation
- Tachycardia
- Hyperexcitability
- Tremors
- Seizures (CNS stimulation)
- Bone marrow suppression
- Diarrhea
- Vomiting
- Diarrhoea
- Excitability
- Arrhythmias
- Hypotension
- Syncope
注意事項與禁忌
- Prior sensitivity to any tricyclic antidepressant
- Concomitant use with monoamine oxidase inhibitors (MAOIs) within 14 days
- Glaucoma
- History of seizures
- Urinary retention
- Severe liver disease
- Hypersensitivity to tricyclic antidepressants
- Use with extreme caution in patients with **seizure disorders**, as imipramine may lower the seizure threshold. **Pregnancy Warning:** There are isolated reports of limb reduction abnormalities (teratogenic potential). Restrict use in pregnant animals to situations where benefits clearly outweigh the risks (FDA Category D in humans). **Nursing:** Excreted into milk in low concentrations (milk:plasma ratio 0.4 to 1.5).
藥物相互作用
- Anticholinergic agents: Additive anticholinergic effects; use cautiously
- Cimetidine: May inhibit tricyclic antidepressant metabolism and increase the risk of toxicity
- CNS Depressants: Additive CNS depressant effects; use cautiously
- Levodopa: Imipramine may decrease levodopa oral absorption
- Phenobarbital: May decrease tricyclic levels
- Quinidine: Increased risk for QTc interval prolongation and tricyclic adverse effects
- Rifampin: May decrease tricyclic blood levels
- SSRIs (e.g., fluoxetine, paroxetine, sertraline): Increased risk for serotonin syndrome
- Sympathomimetic agents: May increase the risk of cardiac effects (arrhythmias, hypertension, hyperpyrexia)
- Monoamine Oxidase Inhibitors (including amitraz, selegiline): Concomitant use (within 14 days) is generally contraindicated due to risk of serotonin syndrome
- Thyroid agents: May increase risk for cardiac arrhythmias
常見問題
Imipramine用於寵物有甚麼用途？
- **Patience is Key**: Behavioral changes may take **several weeks** to become noticeable. Continue dosing as prescribed and do not stop the medication abruptly without consulting your veterinarian. - **Safety First**: This medication is **highly toxic in overdose** to both animals and humans. Keep it in child-resistant packaging, securely locked away from pets and children. - **Side Effects**: You may notice your pet becoming sleepy, having a dry mouth, or experiencing constipation. If your pet seems overly excited, trembles, or has a seizure, contact your vet immediately. - **Missed Doses**: If you miss a dose, give it when you remember, but never double up on doses.
Imipramine對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。