Ifosfamide
別名: Ifex, Holoxan, Holaxane, Mitoxana, Asoifos, Cuantil, Duvaxan, Fentul, IFO-cell, IFX, Ifocris, Ifolem, Ifomida, Ifos, Ifosmixan, Ifoxan, Seromida, Troxanol
> **Important Safety Warning**: Ifosfamide is a potent chemotherapy drug with a high risk of severe side effects. It is often used as an investigational treatment in veterinary medicine. - **Handling Precautions**: This drug is excreted in your pet's bodily fluids. **Avoid direct contact with your pet's saliva or urine for at least 24 hours** after treatment. Use gloves when cleaning up waste. - **Side Effects**: Watch closely for signs of infection, bleeding, vomiting, or neurological changes (confusion, extreme sleepiness, or abnormal behavior). - **Hospitalization**: Treatment requires long intravenous infusions with extra fluids and protective medications (mesna) to safeguard the bladder and kidneys.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Vaccine-related sarcomas
- Neoplasia
- Lymphomas and soft tissue sarcomas
- Lymphomas and soft tissue sarcomas
給藥方式
可能的副作用
- Myelosuppression (neutropenia at 5-7 days, potentially delayed to 14-21 days; thrombocytopenia)
- Hemorrhagic cystitis (bladder epithelial damage)
- Nephrotoxicity (proximal and distal tubular damage, electrolyte abnormalities)
- Volume overload and pulmonary edema (secondary to required saline diuresis)
- Neurotoxicity (somnolence, confusion, coma, encephalopathy)
- Gastrointestinal effects (nausea, vomiting, anorexia)
- Hypersensitivity reactions
- Alopecia
- Abnormal liver function tests
注意事項與禁忌
- Hypersensitivity to ifosfamide
- Severely depressed bone marrow function
- Active hemorrhagic cystitis
- Because of its toxicity, ifosfamide should only be used by clinicians experienced with cytotoxic agents. Must be used in conjunction with mesna and saline diuresis to reduce the risk of hemorrhagic cystitis and nephrotoxicity. Use with extreme caution in patients with impaired renal function or preexisting cardiac disease (due to volume overload risk). Handle and dispose of as a hazardous cytotoxic drug. FDA Category D for pregnancy (teratogenic and fetotoxic).
藥物相互作用
- Benzodiazepines (diazepam, chlordiazepoxide, oxazepam): May increase concentrations of active ifosfamide and increase toxicity (demonstrated in mice; clinical significance in veterinary patients undetermined)
- Cisplatin: Ifosfamide may enhance cisplatin-induced ototoxicity and nephrotoxicity
- Myelosuppressive drugs (chloramphenicol, flucytosine, amphotericin B, colchicine, other antineoplastics): Additive myelosuppression
常見問題
Ifosfamide用於寵物有甚麼用途？
> **Important Safety Warning**: Ifosfamide is a potent chemotherapy drug with a high risk of severe side effects. It is often used as an investigational treatment in veterinary medicine. - **Handling Precautions**: This drug is excreted in your pet's bodily fluids. **Avoid direct contact with your pet's saliva or urine for at least 24 hours** after treatment. Use gloves when cleaning up waste. - **Side Effects**: Watch closely for signs of infection, bleeding, vomiting, or neurological changes (confusion, extreme sleepiness, or abnormal behavior). - **Hospitalization**: Treatment requires long intravenous infusions with extra fluids and protective medications (mesna) to safeguard the bladder and kidneys.
Ifosfamide對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。