Hemoglobin glutamer-200 (bovine)

用途

• As an option to provide oxygen carrying capacity in the trauma patient
• Labeled indications (anemia)
• Resuscitation of trauma patients in shock with or without hemorrhage
• To provide a 'bridge' until immunosuppressive drugs take effect in dogs with IMHA with a transfusion reaction
• As an option to provide oxygen carrying capacity in the trauma patient
• As a vasopressor once there is adequate intravascular volume in trauma patients

給藥方式

可能的副作用

• Discolored mucous membranes, sclera, skin (yellow, red, brown)
• Discolored urine (orange, red, brown)
• Increased central venous pressure (CVP)
• Ventricular arrhythmias (AV block, tachycardia, VPCs)
• Vomiting, diarrhea, anorexia
• Tachypnea, dyspnea, harsh lung sounds
• Pulmonary edema and pleural effusion (due to volume overload)
• Fever
• Peripheral edema
• Hemoglobinuria

注意事項與禁忌

• Advanced cardiac disease (e.g., congestive heart failure)
• Severely impaired cardiac function
• Renal impairment with oliguria or anuria
• HG-200 is a potent colloid and can cause severe vasoconstriction. Extreme care must be taken to avoid volume overload, which can lead to increased hydrostatic pressure, pulmonary edema, and pleural effusion (particularly important in cats). The volume required for fluid resuscitation is approximately 1/3 that of hetastarch. May cause immunologic reactions (IgG antibodies), though anaphylaxis is rare. **Laboratory Interference**: HG-200 severely impacts colorimetric laboratory tests, optical coagulation assays, and urine dipsticks. PCV and RBC counts are inaccurate measures of anemia for 24 hours post-administration due to dilutional effects.

常見問題