Firocoxib

用途

• Experimentally induced pyrexia (Unapproved/Investigational)
• Contraindicated
• Control of pain and inflammation associated with osteoarthritis
• Control of pain and inflammation associated with osteoarthritis
• Pain and inflammation (osteoarthritis, surgery)

給藥方式

可能的副作用

• Dogs: Vomiting, decreased appetite/anorexia, diarrhea, melena, GI ulcers, bloody vomiting, GI perforation
• Dogs: Increases in BUN, creatinine, alkaline phosphatase (ALP), and ALT
• Dogs: Depression/lethargy, ataxia
• Horses: Diarrhea/loose stools, mouth ulcers, facial skin lesions, excitation (rare)
• Gastrointestinal signs (vomiting, diarrhea, inappetence)
• Gastrointestinal ulceration or bleeding
• Renal toxicity (especially during hypotensive states)
• Hepatotoxicity (rare, but liver disease prolongs metabolism)

注意事項與禁忌

• Hypersensitivity to firocoxib or other NSAIDs
• Active GI ulcerative conditions (relative contraindication)
• Bleeding disorders or thrombocytopenia (relative contraindication)
• Dogs weighing less than 7 lbs
• Puppies less than 7 months old (US labeling) or less than 10 weeks old (UK labeling)
• Horses less than 1 year old
• Breeding, pregnant, or lactating dogs or horses (safety not established)
• Cats
• Dogs < 10 weeks of age or < 3 kg body weight
• Pregnant or lactating bitches
• Dehydrated, hypovolaemic, or hypotensive patients
• Patients with pre-existing gastrointestinal disease or bleeding
• Patients with blood clotting disorders

藥物相互作用

• ACE Inhibitors (e.g., enalapril, benazepril): Some NSAIDs can reduce effects on blood pressure
• Aspirin: May increase the risk of gastrointestinal toxicity (ulceration, bleeding, vomiting, diarrhea)
• Corticosteroids (e.g., prednisone): May increase the risk of gastrointestinal toxicity (ulceration, bleeding, vomiting, diarrhea)
• Digoxin: NSAIDs may increase serum levels
• Fluconazole: Administration has increased plasma levels of celecoxib in humans and potentially could also affect firocoxib levels in dogs
• Furosemide: NSAIDs may reduce the saluretic and diuretic effects
• Highly Protein Bound Drugs (phenytoin, valproic acid, oral anticoagulants, sulfonamides, etc.): May displace other highly bound drugs or be displaced by them, potentially increasing serum levels, duration of action, and toxicity
• Methotrexate: Serious toxicity has occurred when NSAIDs have been used concomitantly; use together with extreme caution
• Nephrotoxic Drugs (e.g., aminoglycosides, amphotericin B): May enhance the risk of nephrotoxicity development
• Other NSAIDs: Increased risk of severe gastrointestinal ulceration and renal toxicity. A 3-5 day wash-out period is required.

常見問題