Filgrastim
別名: Neupogen, Filgen, Gran, Granulen, Granulokine, Neulasta, Neutromax
Your veterinarian has prescribed **filgrastim** to help your pet's bone marrow produce more white blood cells (specifically neutrophils), which are critical for fighting off severe infections. * **Cost:** This medication is a human recombinant product and is very expensive. * **Important Risks:** Because this is a human protein, your pet's immune system may recognize it as foreign and create antibodies against it. If this happens, the immune system may destroy both the drug and your pet's own natural white blood cells, leading to a life-threatening drop in immunity. * **Short-term Use:** To minimize this risk, filgrastim is usually only given for a very short period (3 to 5 days) to get your pet through the most critical phase of their illness. * **Monitoring:** Frequent blood tests will be required to ensure the medication is working and to watch for any adverse immune reactions.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Adjunctive therapy of neutropenia (secondary to drug induced aplastic pancytopenia)
- Neutropenia
- Neutropenia
- Neutropenia secondary to drug toxicity, infectious diseases, FeLV associated cyclic neutropenia or idiopathic causes
- Neutropenia
- Adjunctive therapy of neutropenia
- Neutropenia
給藥方式
可能的副作用
- Severe neutropenia (due to autoantibody formation against G-CSF)
- Myelofibrosis (theoretical/reported concern)
- Medullary histiocytosis (theoretical/reported concern)
- Injection site irritation
- Bone pain
- Splenomegaly
- Hypotension
注意事項與禁忌
- Hypersensitivity to filgrastim
- Patients that have previously developed antibodies to filgrastim with resultant neutropenia
- > **High Risk of Immunogenicity:** The development of neutralizing antibodies can cause severe, prolonged neutropenia. Use should generally be restricted to short pulse therapy (≤ 5 days). * **Pregnancy:** FDA Category C. High doses have shown adverse effects in pregnant laboratory animals. Use only when benefits clearly outweigh risks. * **Nursing:** Unknown if excreted in milk, but unlikely to pose significant risk to nursing offspring. * **Efficacy vs. Risk:** Use is controversial due to cost, antibody potential, and lack of definitive evidence showing reduced mortality compared to aggressive broad-spectrum antibiotic therapy alone.
藥物相互作用
- Antineoplastics: Avoid using filgrastim within 24 hours of administering antineoplastic agents that target rapidly proliferating cells, as it may exacerbate toxicity to the newly stimulated myeloid cells.
- Corticosteroids: May potentiate the release of neutrophils during G-CSF therapy.
- Lithium: May potentiate the release of neutrophils during G-CSF therapy.
- Cytotoxic Chemotherapy: Concurrent administration may increase the incidence of adverse effects. The stimulatory effects of G-CSF on haemopoietic precursors render them more susceptible to the effects of chemotherapy.
常見問題
Filgrastim用於寵物有甚麼用途？
Your veterinarian has prescribed **filgrastim** to help your pet's bone marrow produce more white blood cells (specifically neutrophils), which are critical for fighting off severe infections. * **Cost:** This medication is a human recombinant product and is very expensive. * **Important Risks:** Because this is a human protein, your pet's immune system may recognize it as foreign and create antibodies against it. If this happens, the immune system may destroy both the drug and your pet's own natural white blood cells, leading to a life-threatening drop in immunity. * **Short-term Use:** To minimize this risk, filgrastim is usually only given for a very short period (3 to 5 days) to get your pet through the most critical phase of their illness. * **Monitoring:** Frequent blood tests will be required to ensure the medication is working and to watch for any adverse immune reactions.
Filgrastim對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。