Epirubicin
別名: Pharmorubicin
Epirubicin is a potent chemotherapy drug used to treat various cancers in pets. - **Handling:** Chemotherapy drugs can be hazardous. Follow your veterinarian's instructions for handling your pet's waste (urine/feces) for a few days after treatment. - **Side Effects:** Watch for loss of appetite, vomiting, or diarrhea. Contact your vet immediately if these occur. - **Heart Health:** This drug can occasionally affect the heart, so your vet may recommend heart monitoring (like an ECG or ultrasound) before and during treatment. - **Infection Risk:** Your pet's white blood cell count may drop, making them more susceptible to infections. Keep them away from sick animals.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Feline injection site sarcoma
- Lymphoma, splenic haemangiosarcoma, histiocytic sarcoma, and other sarcomas/carcinomas
給藥方式
可能的副作用
- Acute anaphylaxis
- Dose-dependent cumulative cardiotoxicity (cardiomyopathy, congestive heart failure)
- Tachycardia and arrhythmias (during administration)
- Anorexia
- Vomiting
- Pancreatitis
- Severe leucopenia
- Thrombocytopenia
- Haemorrhagic gastroenteritis
- Nephrotoxicity
- Severe tissue necrosis (if extravasated)
注意事項與禁忌
- No specific absolute contraindications listed, but use with extreme caution in patients with pre-existing cardiac disease or the ABCB1 (MDR1) mutation.
- > **Extravasation Risk:** Severe tissue necrosis will occur if extravasated. Use of an indwelling catheter taped in place is essential. Administer into the side port of a freely running IV infusion of 0.9% NaCl over a minimum of 10 minutes. > **Cardiotoxicity:** May cause dose-dependent cumulative cardiotoxicity, though possibly at a lower incidence than doxorubicin. Caution in patients with pre-existing cardiac disease. > **Myelosuppression:** Suspend treatment if neutrophils drop below 2.5 × 10^9/L or platelets below 50 × 10^9/L. Reduce dose by 10-25% if haematological or GI toxicity is recurrent. > **Genetics:** Dogs with the **ABCB1 (MDR1)** mutation may be at higher risk of toxicity. **Clinical Pearl:** Premedication with IV chlorphenamine or dexamethasone is recommended to prevent acute anaphylactic reactions.
藥物相互作用
- Heparin: Incompatible; a precipitate will form if mixed.
- Cyclophosphamide: Increased risk of myelosuppression when used in combination.
- Cimetidine: Increases the area under the dose curve (AUC) of epirubicin by 50%; should not be used concurrently.
常見問題
Epirubicin用於寵物有甚麼用途？
Epirubicin is a potent chemotherapy drug used to treat various cancers in pets. - **Handling:** Chemotherapy drugs can be hazardous. Follow your veterinarian's instructions for handling your pet's waste (urine/feces) for a few days after treatment. - **Side Effects:** Watch for loss of appetite, vomiting, or diarrhea. Contact your vet immediately if these occur. - **Heart Health:** This drug can occasionally affect the heart, so your vet may recommend heart monitoring (like an ECG or ultrasound) before and during treatment. - **Infection Risk:** Your pet's white blood cell count may drop, making them more susceptible to infections. Keep them away from sick animals.
Epirubicin對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。